Reactome | NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages

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NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages Show undefined attributes

catalystActivity	[CatalystActivity:10674998] metal cation:proton antiporter activity of SLC11A1 [late endosome membrane]
category	transition
compartment	[Compartment:172574] late endosome membrane [Compartment:70101] cytosol [Compartment:1222282] phagocytic vesicle lumen
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10675000
displayName	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages
eventOf	[Pathway:R-XTR-6803544] Ion influx/efflux at host-pathogen interface - Xenopus tropicalis [Pathway:R-XTR-425410] Metal ion SLC transporters - Xenopus tropicalis [Pathway:R-XTR-1222556] ROS and RNS production in phagocytes - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Homo sapiens
input	[DefinedSet:R-ALL-445829] Divalent metals transported by NRAMP1 [cytosol] [SimpleEntity:R-ALL-1470067] H+ [phagocytic vesicle lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages
output	[DefinedSet:R-ALL-445832] Divalent metals transported by NRAMP1 [phagocytic vesicle lumen] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-XTR-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-XTR-442422] SLC39A1-4 transports Zn2+ from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-XTR-442317] ZIP6 and ZIP14 mediate zinc influx into cells - Xenopus tropicalis [Reaction:R-XTR-442393] ZIP7 mediates zinc efflux from the endoplasmic reticulum - Xenopus tropicalis [Reaction:R-XTR-442387] ZIP8 mediates zinc influx into cells - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-435171
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-425410] Metal ion SLC transporters [Pathway:R-XTR-1222556] ROS and RNS production in phagocytes [Pathway:R-XTR-6803544] Ion influx/efflux at host-pathogen interface
(inferredTo)	[Reaction:R-HSA-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages