Reactome | NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages

NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages

Stable Identifier

R-HSA-435171

Type

Reaction [transition]

Species

Homo sapiens

Compartment

late endosome membrane, cytosol, phagocytic vesicle lumen

ReviewStatus

5/5

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NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages

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Natural resistance-associated macrophage proteins (NRAMPs) regulate macrophage activation for antimicrobial activity against intracellular pathogens. They do this by mediating bivalent metal ion transport across macrophage membranes and the subsequent use of these ions in the Fenton/and or Haber–Weiss reactions of free radical formation.
The human gene SLC11A1 encodes NRAMP1 (Kishi F, 2004; Kishi F and Nobumoto M, 1995) which can utilize the protonmotive force to mediate divalent iron (Fe2+), zinc (Zn2+) and manganese (Mn2+) influx to or efflux from phagosomes in an antiport mechanism (Goswami et al., 2001).

Literature References

PubMed ID	Title	Journal	Year
11237855	Natural-resistance-associated macrophage protein 1 is an H+/bivalent cation antiporter Goswami, T, Bhattacharjee, A, Babal, P, Searle, S, Moore, E, Li, M, Blackwell, JM	Biochem J	2001
7980580	Isolation and characterization of human Nramp cDNA Kishi, F	Biochem Biophys Res Commun	1994
8537108	Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes Kishi, F, Nobumoto, M	Immunol Lett	1995