NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages

Stable Identifier
R-HSA-435171
Type
Reaction [transition]
Species
Homo sapiens
Compartment
late endosome membrane, cytosol, phagocytic vesicle lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Natural resistance-associated macrophage proteins (NRAMPs) regulate macrophage activation for antimicrobial activity against intracellular pathogens. They do this by mediating bivalent metal ion transport across macrophage membranes and the subsequent use of these ions in the Fenton/and or Haber–Weiss reactions of free radical formation.
The human gene SLC11A1 encodes NRAMP1 (Kishi F, 2004; Kishi F and Nobumoto M, 1995) which can utilize the protonmotive force to mediate divalent iron (Fe2+), zinc (Zn2+) and manganese (Mn2+) influx to or efflux from phagosomes.
Literature References
PubMed ID Title Journal Year
8537108 Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes

Kishi, F, Nobumoto, M

Immunol Lett 1995
7980580 Isolation and characterization of human Nramp cDNA

Kishi, F

Biochem Biophys Res Commun 1994
Participants
Input
Output
Participates
as an event of
Catalyst Activity

metal cation:proton antiporter activity of SLC11A1 [late endosome membrane]

Physical Entity
SLC11A1 [late endosome membrane] (Homo sapiens)
Activity
metal cation:proton antiporter activity (GO:0051139)
Orthologous Events
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Danio rerio)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Plasmodium falciparum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Rattus norvegicus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Sus scrofa)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2009-09-07)
Reviewed
He, L  (2009-11-12)
Created
Jassal, B  (2009-09-07)
Cite Us!