Reactome | Lsm1-7 Complex binds deadenylated mRNA

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Lsm1-7 Complex binds deadenylated mRNA Show undefined attributes

authored	[InstanceEdit:430015] May, B, 2009-07-22
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:429836] May, B, 2009-07-23
dbId	429978
displayName	Lsm1-7 Complex binds deadenylated mRNA
edited	[InstanceEdit:430015] May, B, 2009-07-22
eventOf	[Pathway:R-HSA-430039] mRNA decay by 5' to 3' exoribonuclease - Homo sapiens
followingEvent	[Reaction:R-HSA-429860] DCP1-DCP2 complex decaps mRNA - Homo sapiens
input	[Complex:R-HSA-430001] Lsm1-7 Complex [cytosol] [OtherEntity:R-ALL-429974] mature mRNA (eukaryotic, capped and deadenylated) [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:429900] Reconstitution of two recombinant LSm protein complexes reveals aspects of their architecture, assembly, and function [LiteratureReference:429975] Lsm1-7-Pat1 complex: A link between 3' and 5'-ends in mRNA decay? [LiteratureReference:430033] LSm proteins form heptameric rings that bind to RNA via repeating motifs [LiteratureReference:433045] A protein interaction framework for human mRNA degradation [LiteratureReference:429957] The highways and byways of mRNA decay [LiteratureReference:429946] Messenger RNA decay in mammalian cells: the exonuclease perspective [LiteratureReference:429954] The many pathways of RNA degradation [LiteratureReference:430040] From birth to death: the complex lives of eukaryotic mRNAs [LiteratureReference:429833] The enzymes and control of eukaryotic mRNA turnover [LiteratureReference:430007] The cap-to-tail guide to mRNA turnover
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Lsm1-7 Complex binds deadenylated mRNA
negativePrecedingEvent	[NegativePrecedingEvent:9764209] Futile Cycle: 5' to 3' exoribonuclease hydrolyzes decapped mRNA
orthologousEvent	[Reaction:R-PFA-429978] Lsm1-7 Complex binds deadenylated mRNA - Plasmodium falciparum [Reaction:R-SCE-429978] Lsm1-7 Complex binds deadenylated mRNA - Saccharomyces cerevisiae [Reaction:R-SPO-429978] Lsm1-7 Complex binds deadenylated mRNA - Schizosaccharomyces pombe [Reaction:R-DDI-429978] Lsm1-7 Complex binds deadenylated mRNA - Dictyostelium discoideum [Reaction:R-CEL-429978] Lsm1-7 Complex binds deadenylated mRNA - Caenorhabditis elegans [Reaction:R-DME-429978] Lsm1-7 Complex binds deadenylated mRNA - Drosophila melanogaster [Reaction:R-GGA-429978] Lsm1-7 Complex binds deadenylated mRNA - Gallus gallus [Reaction:R-XTR-429978] Lsm1-7 Complex binds deadenylated mRNA - Xenopus tropicalis [Reaction:R-DRE-429978] Lsm1-7 Complex binds deadenylated mRNA - Danio rerio [Reaction:R-SSC-429978] Lsm1-7 Complex binds deadenylated mRNA - Sus scrofa [Reaction:R-BTA-429978] Lsm1-7 Complex binds deadenylated mRNA - Bos taurus [Reaction:R-CFA-429978] Lsm1-7 Complex binds deadenylated mRNA - Canis familiaris [Reaction:R-RNO-429978] Lsm1-7 Complex binds deadenylated mRNA - Rattus norvegicus [Reaction:R-MMU-429978] Lsm1-7 Complex binds deadenylated mRNA - Mus musculus
output	[Complex:R-HSA-429908] Deadenylated mRNA:Lsm1-7 Complex [cytosol]
precedingEvent	[Reaction:R-HSA-429992] PARN deadenylates mRNA - Homo sapiens [Reaction:R-HSA-429955] CCR4-NOT complex deadenylates mRNA - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:442431] Wilusz, J, 2009-09-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-429978
summation	[Summation:429948] The Lsm1-7 complex forms a heptameric ring that binds the 3'...

Referrals

(hasEvent)	[Pathway:R-HSA-430039] mRNA decay by 5' to 3' exoribonuclease
(precedingEvent)	[Reaction:R-HSA-429860] DCP1-DCP2 complex decaps mRNA

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