Reactome | DCP1-DCP2 complex decaps mRNA

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DCP1-DCP2 complex decaps mRNA Show undefined attributes

authored	[InstanceEdit:430015] May, B, 2009-07-22
catalystActivity	[CatalystActivity:429920] RNA exonuclease activity, producing 5'-phosphomonoesters of DCP1-DCP2 Decapping Complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:429836] May, B, 2009-07-23
dbId	429860
displayName	DCP1-DCP2 complex decaps mRNA
edited	[InstanceEdit:430015] May, B, 2009-07-22
eventOf	[Pathway:R-HSA-430039] mRNA decay by 5' to 3' exoribonuclease - Homo sapiens
followingEvent	[Reaction:R-HSA-429845] 5' to 3' exoribonuclease hydrolyzes decapped mRNA - Homo sapiens
input	[Complex:R-HSA-429908] Deadenylated mRNA:Lsm1-7 Complex [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:433069] The hDcp2 protein is a mammalian mRNA decapping enzyme [LiteratureReference:433068] Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay [LiteratureReference:433076] Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures [LiteratureReference:433066] Functional characterization of the mammalian mRNA decapping enzyme hDcp2 [LiteratureReference:429998] Transcript-specific decapping and regulated stability by the human Dcp2 decapping protein [LiteratureReference:429916] Decapping the message: a beginning or an end [LiteratureReference:429829] The control of mRNA decapping and P-body formation [LiteratureReference:433075] Poly(A)-binding-protein-mediated regulation of hDcp2 decapping in vitro [LiteratureReference:429957] The highways and byways of mRNA decay [LiteratureReference:429946] Messenger RNA decay in mammalian cells: the exonuclease perspective [LiteratureReference:429954] The many pathways of RNA degradation [LiteratureReference:430040] From birth to death: the complex lives of eukaryotic mRNAs [LiteratureReference:429833] The enzymes and control of eukaryotic mRNA turnover [LiteratureReference:430007] The cap-to-tail guide to mRNA turnover
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	DCP1-DCP2 complex decaps mRNA
orthologousEvent	[Reaction:R-PFA-429860] DCP1-DCP2 complex decaps mRNA - Plasmodium falciparum [Reaction:R-SCE-429860] DCP1-DCP2 complex decaps mRNA - Saccharomyces cerevisiae [Reaction:R-DDI-429860] DCP1-DCP2 complex decaps mRNA - Dictyostelium discoideum [Reaction:R-CEL-429860] DCP1-DCP2 complex decaps mRNA - Caenorhabditis elegans [Reaction:R-DME-429860] DCP1-DCP2 complex decaps mRNA - Drosophila melanogaster [Reaction:R-GGA-429860] DCP1-DCP2 complex decaps mRNA - Gallus gallus [Reaction:R-XTR-429860] DCP1-DCP2 complex decaps mRNA - Xenopus tropicalis [Reaction:R-DRE-429860] DCP1-DCP2 complex decaps mRNA - Danio rerio [Reaction:R-SSC-429860] DCP1-DCP2 complex decaps mRNA - Sus scrofa [Reaction:R-BTA-429860] DCP1-DCP2 complex decaps mRNA - Bos taurus [Reaction:R-CFA-429860] DCP1-DCP2 complex decaps mRNA - Canis familiaris [Reaction:R-RNO-429860] DCP1-DCP2 complex decaps mRNA - Rattus norvegicus [Reaction:R-MMU-429860] DCP1-DCP2 complex decaps mRNA - Mus musculus
output	[SimpleEntity:R-ALL-430004] 7-MeGDP [cytosol] [Complex:R-HSA-429996] Decapped mRNA:LSM1-7 Complex [cytosol]
precedingEvent	[Reaction:R-HSA-429978] Lsm1-7 Complex binds deadenylated mRNA - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:442431] Wilusz, J, 2009-09-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-429860
summation	[Summation:429919] The DCP1-DCP2 decapping complex binds the 7-methylguanosine ...

Referrals

(hasEvent)	[Pathway:R-HSA-430039] mRNA decay by 5' to 3' exoribonuclease
(precedingEvent)	[Reaction:R-HSA-429845] 5' to 3' exoribonuclease hydrolyzes decapped mRNA

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