Reactome | Lsm1-7 Complex binds deadenylated mRNA

Lsm1-7 Complex binds deadenylated mRNA

Stable Identifier

R-HSA-429978

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The Lsm1-7 complex forms a heptameric ring that binds the 3' oligoadenylated ends of mRNAs that have been deadenylated. The bound Lsm1-7 may prevent access of the exosome (a 3' to 5' exonuclease) to the 3' end and thereby direct the mRNA to the 5' to 3' exonuclease pathway. The yeast Lsm1-7 complex has a preference for oligoadenylated RNA compared to polyadenylated RNA, however other determinants of binding by Lsm1-7 are unknown.

Literature References

PubMed ID	Title	Journal	Year
14749774	The enzymes and control of eukaryotic mRNA turnover Song, H, Parker, R	Nat Struct Mol Biol	2004
16141059	From birth to death: the complex lives of eukaryotic mRNAs Moore, MJ	Science	2005
15475613	Messenger RNA decay in mammalian cells: the exonuclease perspective Fritz, DT, Wilusz, J, Bergman, N, Wilusz, CJ, Kilpatrick, WJ	Cell Biochem Biophys	2004
15711010	Reconstitution of two recombinant LSm protein complexes reveals aspects of their architecture, assembly, and function Engel, A, Winkler, FK, Zaric, B, Ballmer-Hofer, K, Rémigy, H, Kambach, C, Chami, M	J Biol Chem	2005
16051491	LSm proteins form heptameric rings that bind to RNA via repeating motifs Plaag, R, Zieve, GW, Khusial, P	Trends Biochem Sci	2005
19239894	The many pathways of RNA degradation Houseley, J, Tollervey, D	Cell	2009
17245413	The highways and byways of mRNA decay Garneau, NL, Wilusz, J, Wilusz, CJ	Nat Rev Mol Cell Biol	2007
15231747	A protein interaction framework for human mRNA degradation Sanderson, CM, Lehner, B	Genome Res	2004
11283721	The cap-to-tail guide to mRNA turnover Wormington, M, Wilusz, CJ, Peltz, SW	Nat Rev Mol Cell Biol	2001
19279404	Lsm1-7-Pat1 complex: A link between 3' and 5'-ends in mRNA decay? Tharun, S	RNA Biol	2009