The Lsm1-7 complex forms a heptameric ring that binds the 3' oligoadenylated ends of mRNAs that have been deadenylated. The bound Lsm1-7 may prevent access of the exosome (a 3' to 5' exonuclease) to the 3' end and thereby direct the mRNA to the 5' to 3' exonuclease pathway. The yeast Lsm1-7 complex has a preference for oligoadenylated RNA compared to polyadenylated RNA, however other determinants of binding by Lsm1-7 are unknown.
Moore, MJ
Parker, R, Song, H
Fritz, DT, Bergman, N, Kilpatrick, WJ, Wilusz, CJ, Wilusz, J
Zaric, B, Chami, M, Rémigy, H, Engel, A, Ballmer-Hofer, K, Winkler, FK, Kambach, C
Khusial, P, Plaag, R, Zieve, GW
Houseley, J, Tollervey, D
Garneau, NL, Wilusz, J, Wilusz, CJ
Lehner, B, Sanderson, CM
Wilusz, CJ, Wormington, M, Peltz, SW
Tharun, S
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