The Lsm1-7 complex forms a heptameric ring that binds the 3' oligoadenylated ends of mRNAs that have been deadenylated. The bound Lsm1-7 may prevent access of the exosome (a 3' to 5' exonuclease) to the 3' end and thereby direct the mRNA to the 5' to 3' exonuclease pathway. The yeast Lsm1-7 complex has a preference for oligoadenylated RNA compared to polyadenylated RNA, however other determinants of binding by Lsm1-7 are unknown.
Song, H, Parker, R
Moore, MJ
Fritz, DT, Wilusz, J, Bergman, N, Wilusz, CJ, Kilpatrick, WJ
Engel, A, Winkler, FK, Zaric, B, Ballmer-Hofer, K, Rémigy, H, Kambach, C, Chami, M
Plaag, R, Zieve, GW, Khusial, P
Houseley, J, Tollervey, D
Garneau, NL, Wilusz, J, Wilusz, CJ
Sanderson, CM, Lehner, B
Wormington, M, Wilusz, CJ, Peltz, SW
Tharun, S
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