Reactome | mRNA decay by 5' to 3' exoribonuclease

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mRNA decay by 5' to 3' exoribonuclease Show undefined attributes

authored	[InstanceEdit:430015] May, B, 2009-07-22
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:429836] May, B, 2009-07-23
dbId	430039
displayName	mRNA decay by 5' to 3' exoribonuclease
edited	[InstanceEdit:430015] May, B, 2009-07-22
eventOf	[Pathway:R-HSA-429914] Deadenylation-dependent mRNA decay - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:22759] nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-429978] Lsm1-7 Complex binds deadenylated mRNA - Homo sapiens [Reaction:R-HSA-429860] DCP1-DCP2 complex decaps mRNA - Homo sapiens [Reaction:R-HSA-429845] 5' to 3' exoribonuclease hydrolyzes decapped mRNA - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2012-03-31
literatureReference	[LiteratureReference:429957] The highways and byways of mRNA decay [LiteratureReference:429946] Messenger RNA decay in mammalian cells: the exonuclease perspective [LiteratureReference:429954] The many pathways of RNA degradation [LiteratureReference:430040] From birth to death: the complex lives of eukaryotic mRNAs [LiteratureReference:429833] The enzymes and control of eukaryotic mRNA turnover [LiteratureReference:430007] The cap-to-tail guide to mRNA turnover [LiteratureReference:2028614] Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	mRNA decay by 5' to 3' exoribonuclease
orthologousEvent	[Pathway:R-PFA-430039] mRNA decay by 5' to 3' exoribonuclease - Plasmodium falciparum [Pathway:R-SCE-430039] mRNA decay by 5' to 3' exoribonuclease - Saccharomyces cerevisiae [Pathway:R-SPO-430039] mRNA decay by 5' to 3' exoribonuclease - Schizosaccharomyces pombe [Pathway:R-DDI-430039] mRNA decay by 5' to 3' exoribonuclease - Dictyostelium discoideum [Pathway:R-CEL-430039] mRNA decay by 5' to 3' exoribonuclease - Caenorhabditis elegans [Pathway:R-DME-430039] mRNA decay by 5' to 3' exoribonuclease - Drosophila melanogaster [Pathway:R-GGA-430039] mRNA decay by 5' to 3' exoribonuclease - Gallus gallus [Pathway:R-XTR-430039] mRNA decay by 5' to 3' exoribonuclease - Xenopus tropicalis [Pathway:R-DRE-430039] mRNA decay by 5' to 3' exoribonuclease - Danio rerio [Pathway:R-SSC-430039] mRNA decay by 5' to 3' exoribonuclease - Sus scrofa [Pathway:R-BTA-430039] mRNA decay by 5' to 3' exoribonuclease - Bos taurus [Pathway:R-CFA-430039] mRNA decay by 5' to 3' exoribonuclease - Canis familiaris [Pathway:R-RNO-430039] mRNA decay by 5' to 3' exoribonuclease - Rattus norvegicus [Pathway:R-MMU-430039] mRNA decay by 5' to 3' exoribonuclease - Mus musculus
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:442431] Wilusz, J, 2009-09-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-430039
summation	[Summation:429859] Degradation of mRNA from 5' to 3' occurs in three steps. Fir...
updateTrackers	[UpdateTracker:9788730] Update Tracker - [Pathway:430039] mRNA decay by 5' to 3' exoribonuclease - v40:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788730] Update Tracker - [Pathway:430039] mRNA decay by 5' to 3' exoribonuclease - v40:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-429914] Deadenylation-dependent mRNA decay

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