sphinganine + stearyl-CoA => dihydroceramide + CoASH

Stable Identifier
Reaction [transition]
Homo sapiens
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LASS (longevity assurance homolog, also known as ceramide synthase, CerS) enzymes associated with the endoplasmic reticulum membrane catalyze the reaction of sphinganine (dihydrosphingosine) and a long-chain fatty acyl CoA such as stearyl-CoA to form a dihydroceramide and CoASH (Pewzner-Jung et al. 2006). Six human LASS genes have been identified; they differ in the identities of the fatty acyl CoAs that they use most efficiently as substrates (Lahiri and Futerman 2005; Laviad et al. 2008).

Literature References
PubMed ID Title Journal Year
16793762 When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis

Ben-Dor, S, Pewzner-Jung, Y, Futerman, AH

J Biol Chem 2006
18165233 Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate

Laviad, EL, Merrill AH, Jr, Park, H, Epstein, S, Pankova-Kholmyansky, I, Albee, L, Futerman, AH

J Biol Chem 2008
16100120 LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor

Lahiri, S, Futerman, AH

J Biol Chem 2005
Catalyst Activity

sphingosine N-acyltransferase activity of LASS proteins [endoplasmic reticulum membrane]

Orthologous Events
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