Reactome | sphinganine + stearyl-CoA => dihydroceramide + CoASH

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:433613] sphingosine N-acyltransferase activity of LASS proteins [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:433625] D'Eustachio, P, 2009-08-22
dbId	433592
displayName	sphinganine + stearyl-CoA => dihydroceramide + CoASH
eventOf	[Pathway:R-GGA-433584] Sphingolipid metabolism - Gallus gallus
followingEvent	[Reaction:R-GGA-433593] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O - Gallus gallus [Reaction:R-GGA-433599] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O - Gallus gallus
inferredFrom	[Reaction:R-HSA-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Homo sapiens
input	[SimpleEntity:R-ALL-428163] SPA [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-428139] ST-CoA [cytosol]
isInDisease	false
isInferred	true
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	sphinganine + stearyl-CoA => dihydroceramide + CoASH
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-428126] DHCE [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-GGA-433576] 3-dehydrosphinganine + NADPH + H+ => sphinganine + NADP+ - Gallus gallus
releaseDate	2008-09-30
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-433592
summation	[Summation:433555] LASS (ceramide synthase / "longevity assurance homolog") enz...

(hasEvent)	[Pathway:R-GGA-433584] Sphingolipid metabolism
(precedingEvent)	[Reaction:R-GGA-433593] dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O [Reaction:R-GGA-433599] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O
(inferredTo)	[Reaction:R-HSA-428185] Ceramide synthases transfer acyl-CoA onto sphingoid

Cite Us!