Reactome | Ceramide synthases transfer acyl-CoA onto sphingoid

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Ceramide synthases transfer acyl-CoA onto sphingoid Show undefined attributes

catalystActivity	[CatalystActivity:10363633] sphingosine N-acyltransferase activity of Ceramide synthases [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10363635
displayName	Ceramide synthases transfer acyl-CoA onto sphingoid
eventOf	[Pathway:R-BTA-1660661] Sphingolipid de novo biosynthesis - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-428259] DEGS1 dehydrogenates dihydroceramide - Bos taurus [Reaction:R-BTA-428260] DEGS2 oxygenates dihydroceramide - Bos taurus
inferredFrom	[Reaction:R-HSA-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Homo sapiens
input	[SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol] [SimpleEntity:R-ALL-5279323] sphingoid base [cytoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Ceramide synthases transfer acyl-CoA onto sphingoid sphingoid + acyl-CoA => dihydroceramide + CoASH
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-428126] DHCE [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-BTA-428123] KDSR reduces 3-ketosphingoid - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-428185
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1660661] Sphingolipid de novo biosynthesis
(precedingEvent)	[Reaction:R-BTA-428259] DEGS1 dehydrogenates dihydroceramide [Reaction:R-BTA-428260] DEGS2 oxygenates dihydroceramide
(inferredTo)	[Reaction:R-HSA-428185] Ceramide synthases transfer acyl-CoA onto sphingoid

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