Cyclic GMP phosphodiesterase are hydrolases selective for cA...

created [InstanceEdit:418565] Jupe, S, 2009-04-23 15:40:54
dbId 418566
displayName Cyclic GMP phosphodiesterase are hydrolases selective for cA...
literatureReference
modified [InstanceEdit:434772] Jupe, S, 2009-09-02
schemaClass Summation
text Cyclic GMP phosphodiesterase are hydrolases selective for cAMP (PDE4, 7 and 8), cGMP (PDE5, 6 and 9) or able to hydrolyse both cAMP and cGMP (PDE1, 2, 3, 10 and 11). The dual-specificity PDEs allow for cross-regulation of the cAMP and cGMP pathways, e.g. PDE2 can hydrolyse both, but binding of cGMP to the regulatory GAF-B domain increases cAMP affinity and hydrolysis.
PDE2, 3 and 5 are expressed in platelets.
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