Reactome | cGMP is degraded by PDEs

cGMP is degraded by PDEs

Stable Identifier

R-HSA-418456

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cyclic GMP phosphodiesterase are hydrolases selective for cAMP (PDE4, 7 and 8), cGMP (PDE5, 6 and 9) or able to hydrolyse both cAMP and cGMP (PDE1, 2, 3, 10 and 11). The dual-specificity PDEs allow for cross-regulation of the cAMP and cGMP pathways, e.g. PDE2 can hydrolyse both, but binding of cGMP to the regulatory GAF-B domain increases cAMP affinity and hydrolysis.
PDE2, 3 and 5 are expressed in platelets.

Literature References

PubMed ID	Title	Journal	Year
8557689	Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases Loughney, K, Martins, TJ, Harris, EA, Sadhu, K, Hicks, JB, Sonnenburg, WK, Beavo, JA, Ferguson, K	J Biol Chem	1996