cGMP is degraded by PDEs

Stable Identifier
R-HSA-418456
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cyclic GMP phosphodiesterase are hydrolases selective for cAMP (PDE4, 7 and 8), cGMP (PDE5, 6 and 9) or able to hydrolyse both cAMP and cGMP (PDE1, 2, 3, 10 and 11). The dual-specificity PDEs allow for cross-regulation of the cAMP and cGMP pathways, e.g. PDE2 can hydrolyse both, but binding of cGMP to the regulatory GAF-B domain increases cAMP affinity and hydrolysis.
PDE2, 3 and 5 are expressed in platelets.

Literature References
PubMed ID Title Journal Year
8557689 Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases

Loughney, K, Martins, TJ, Harris, EA, Sadhu, K, Hicks, JB, Sonnenburg, WK, Beavo, JA, Ferguson, K

J Biol Chem 1996
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
3',5'-cyclic-GMP phosphodiesterase activity of cGMP phosphodiesterases [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!