Reactome | SUMOylation of intracellular receptors

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SUMOylation of intracellular receptors Show undefined attributes

authored	[InstanceEdit:4086098] May, B, 2013-08-06
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4090291] May, B, 2013-08-13
dbId	4090294
displayName	SUMOylation of intracellular receptors
doi	10.3180/R-HSA-4090294.2
edited	[InstanceEdit:4086098] May, B, 2013-08-06
eventOf	[Pathway:R-HSA-3108232] SUMO E3 ligases SUMOylate target proteins - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-4090390] PIAS1,2-1 SUMOylates AR with SUMO1 - Homo sapiens [Reaction:R-HSA-4090408] PIAS1,3 SUMOylate ESR1 with SUMO1 - Homo sapiens [Reaction:R-HSA-4720432] HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 - Homo sapiens [Reaction:R-HSA-4720446] HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 - Homo sapiens [BlackBoxEvent:R-HSA-4755419] SUMOylation of NR1H4 with SUMO1 - Homo sapiens [BlackBoxEvent:R-HSA-4755524] SUMOylation of NR1I2 with SUMO3 - Homo sapiens [Reaction:R-HSA-4717521] PIAS1 SUMOylates NR2C1 (TR2) - Homo sapiens [Reaction:R-HSA-4341025] SUMOylation of NR3C1 (GR) with SUMO1 - Homo sapiens [Reaction:R-HSA-4341016] PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 - Homo sapiens [Reaction:R-HSA-4755526] PIAS4 SUMOylates NR4A2 with SUMO2,3 - Homo sapiens [Reaction:R-HSA-4546386] PIAS1,3 SUMOylates NR5A1 with SUMO1 - Homo sapiens [Reaction:R-HSA-4546385] PIAS1,3 SUMOylates NR5A1 with SUMO2 - Homo sapiens [Reaction:R-HSA-4755494] PIAS1,2-1 SUMOylate NR5A2 with SUMO1 - Homo sapiens [Reaction:R-HSA-4341070] PIAS4 SUMOylates PPARA with SUMO1 - Homo sapiens [Reaction:R-HSA-4717461] PIAS1,2-2 SUMOylate PPARG with SUMO1 - Homo sapiens [Reaction:R-HSA-4341073] PIAS3 SUMOylates PGR with SUMO1 - Homo sapiens [Reaction:R-HSA-4341072] SUMOylation of RARA with SUMO2 - Homo sapiens [Reaction:R-HSA-4719436] PIAS2,3,4 SUMOylate RORA with SUMO1 - Homo sapiens [Reaction:R-HSA-4719413] PIAS2,3,4 SUMOylate RORA with SUMO2 - Homo sapiens [Reaction:R-HSA-4341048] SUMOylation of RXRA with SUMO1 - Homo sapiens [Reaction:R-HSA-4719447] PIAS2-2 SUMOylates THRA with SUMO1 - Homo sapiens [Reaction:R-HSA-4719423] PIAS2-2 SUMOylates THRA with SUMO3 - Homo sapiens [Reaction:R-HSA-4719424] PIAS1 SUMOylates THRB with SUMO1. - Homo sapiens [Reaction:R-HSA-4719448] PIAS1 SUMOylates THRB with SUMO3 - Homo sapiens [Reaction:R-HSA-4546387] PIAS4 SUMOylates VDR with SUMO2 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4686131] Transcriptional control of metabolic and inflammatory pathways by nuclear receptor SUMOylation [LiteratureReference:4663737] The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation [LiteratureReference:4663784] Dynamic regulation of steroid hormone receptor transcriptional activity by reversible SUMOylation [LiteratureReference:5215903] Post-translational modifications of nuclear receptors and human disease
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	SUMOylation of intracellular receptors
orthologousEvent	[Pathway:R-CEL-4090294] SUMOylation of intracellular receptors - Caenorhabditis elegans [Pathway:R-DME-4090294] SUMOylation of intracellular receptors - Drosophila melanogaster [Pathway:R-GGA-4090294] SUMOylation of intracellular receptors - Gallus gallus [Pathway:R-XTR-4090294] SUMOylation of intracellular receptors - Xenopus tropicalis [Pathway:R-DRE-4090294] SUMOylation of intracellular receptors - Danio rerio [Pathway:R-SSC-4090294] SUMOylation of intracellular receptors - Sus scrofa [Pathway:R-BTA-4090294] SUMOylation of intracellular receptors - Bos taurus [Pathway:R-RNO-4090294] SUMOylation of intracellular receptors - Rattus norvegicus [Pathway:R-MMU-4090294] SUMOylation of intracellular receptors - Mus musculus
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-4090294
summation	[Summation:4686126] At least 17 nuclear receptors have been discovered to be SUM...

Referrals

(hasEvent)

[Pathway:R-HSA-3108232] SUMO E3 ligases SUMOylate target proteins

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