Reactome | PIAS4 SUMOylates PPARA with SUMO1

Schema > Reaction > Entries

PIAS4 SUMOylates PPARA with SUMO1 Show undefined attributes

authored	[InstanceEdit:4090429] May, B, 2013-08-13
catalystActivity	[CatalystActivity:3215011] SUMO transferase activity of PIAS4 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643693] SUMO transferase activity of PIAS4 [nucleoplasm] PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4341066] May, B, 2013-08-18
dbId	4341070
displayName	PIAS4 SUMOylates PPARA with SUMO1
edited	[InstanceEdit:4090429] May, B, 2013-08-13
eventOf	[Pathway:R-HSA-4090294] SUMOylation of intracellular receptors - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-400186] PPARA [nucleoplasm] [Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4341049] SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PIAS4 SUMOylates PPARA with SUMO1
orthologousEvent	[Reaction:R-CEL-4341070] PIAS4 SUMOylates PPARA with SUMO1 - Caenorhabditis elegans [Reaction:R-GGA-4341070] PIAS4 SUMOylates PPARA with SUMO1 - Gallus gallus [Reaction:R-DRE-4341070] PIAS4 SUMOylates PPARA with SUMO1 - Danio rerio [Reaction:R-SSC-4341070] PIAS4 SUMOylates PPARA with SUMO1 - Sus scrofa [Reaction:R-BTA-4341070] PIAS4 SUMOylates PPARA with SUMO1 - Bos taurus [Reaction:R-RNO-4341070] PIAS4 SUMOylates PPARA with SUMO1 - Rattus norvegicus [Reaction:R-MMU-4341070] PIAS4 SUMOylates PPARA with SUMO1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-4341099] monoSUMO1-K185-PPARA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4341070
summation	[Summation:4341047] PIAS4 SUMOylates PPARA at lysine-185 with SUMO1 (Pourcet et ...
updateTrackers	[UpdateTracker:9775168] Update Tracker - [Reaction:4341070] PIAS4 SUMOylates PPARA with SUMO1 - v80:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9775168] Update Tracker - [Reaction:4341070] PIAS4 SUMOylates PPARA with SUMO1 - v80:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-4090294] SUMOylation of intracellular receptors