Reactome | HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3

Schema > Reaction > Entries

HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 Show undefined attributes

authored	[InstanceEdit:4719461] May, B, 2013-10-19
catalystActivity	[CatalystActivity:4720450] SUMO transferase activity of HDAC4 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643453] SUMO transferase activity of HDAC4 [nucleoplasm] Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4720447] May, B, 2013-10-20
dbId	4720432
displayName	HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3
edited	[InstanceEdit:4719461] May, B, 2013-10-19
eventOf	[Pathway:R-HSA-4090294] SUMOylation of intracellular receptors - Homo sapiens
input	[Complex:R-HSA-4720431] NR1H2:hydroxycholesterol [nucleoplasm] 4 × [DefinedSet:R-HSA-3899312] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4720443] Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma [LiteratureReference:4755454] GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3
orthologousEvent	[Reaction:R-DME-4720432] HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 - Drosophila melanogaster [Reaction:R-DRE-4720432] HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 - Danio rerio [Reaction:R-SSC-4720432] HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 - Sus scrofa [Reaction:R-BTA-4720432] HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 - Bos taurus [Reaction:R-RNO-4720432] HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 - Rattus norvegicus [Reaction:R-MMU-4720432] HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 - Mus musculus
output	[Complex:R-HSA-4720444] SUMO2,3-NR1H2:hydroxycholesterol [nucleoplasm] 4 × [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993790] Transfer of SUMO2 from E1 to UBE2I (UBC9) - Homo sapiens [Reaction:R-HSA-2993769] Transfer of SUMO3 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4720432
summation	[Summation:4720442] HDAC4 SUMOylates NR1H2 (LXR-beta) with SUMO2,3 at lysine-409...

Referrals

(hasEvent)

[Pathway:R-HSA-4090294] SUMOylation of intracellular receptors