Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
PIAS1 SUMOylates THRB with SUMO3
Show undefined attributes
Go to Details
authored
[InstanceEdit:4717522] May, B, 2013-10-18
catalystActivity
[CatalystActivity:3247478] SUMO transferase activity of PIAS1 [nucleoplasm]
catalystActivityReference
[CatalystActivityReference:9643901] SUMO transferase activity of PIAS1 [nucleoplasm] Transcription factor Sp3 is silenced through SUMO modification by PIAS1
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:4719399] May, B, 2013-10-19
dbId
4719448
displayName
PIAS1 SUMOylates THRB with SUMO3
edited
[InstanceEdit:4717522] May, B, 2013-10-18
eventOf
[Pathway:R-HSA-4090294] SUMOylation of intracellular receptors - Homo sapiens
input
6 ×
[Complex:R-HSA-2993782] SUMO3:UBE2I [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-446179] THRB [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:4719412] Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation
maxDepth
1
modified
[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name
PIAS1 SUMOylates THRB with SUMO3
orthologousEvent
[Reaction:R-DME-4719448] PIAS1 SUMOylates THRB with SUMO3 - Drosophila melanogaster
[Reaction:R-XTR-4719448] PIAS1 SUMOylates THRB with SUMO3 - Xenopus tropicalis
[Reaction:R-DRE-4719448] PIAS1 SUMOylates THRB with SUMO3 - Danio rerio
[Reaction:R-SSC-4719448] PIAS1 SUMOylates THRB with SUMO3 - Sus scrofa
[Reaction:R-BTA-4719448] PIAS1 SUMOylates THRB with SUMO3 - Bos taurus
[Reaction:R-RNO-4719448] PIAS1 SUMOylates THRB with SUMO3 - Rattus norvegicus
[Reaction:R-MMU-4719448] PIAS1 SUMOylates THRB with SUMO3 - Mus musculus
output
[EntityWithAccessionedSequence:R-HSA-4719433] polySUMO3-K50,K146,K443-THRB [nucleoplasm]
6 ×
[EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent
[Reaction:R-HSA-2993769] Transfer of SUMO3 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate
2018-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09
[InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-4719448
summation
[Summation:4719443] PIAS1 SUMOylates THRB with SUMO3 at lysine-50, lysine-146, a...
Referrals
(hasEvent)
[Pathway:R-HSA-4090294] SUMOylation of intracellular receptors
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text