Reactome | PIAS1,3 SUMOylates NR5A1 with SUMO1

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PIAS1,3 SUMOylates NR5A1 with SUMO1 Show undefined attributes

authored	[InstanceEdit:4341133] May, B, 2013-08-18
catalystActivity	[CatalystActivity:4086046] SUMO transferase activity of PIAS1,3 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4546388] May, B, 2013-09-05
dbId	4546386
displayName	PIAS1,3 SUMOylates NR5A1 with SUMO1
edited	[InstanceEdit:4341133] May, B, 2013-08-18
eventOf	[Pathway:R-HSA-4090294] SUMOylation of intracellular receptors - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-452955] NR5A1 [nucleoplasm] 2 × [Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4546348] Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9 [LiteratureReference:4546359] SUMO modification of repression domains modulates function of nuclear receptor 5A1 (steroidogenic factor-1) [LiteratureReference:4546346] Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PIAS1,3 SUMOylates NR5A1 with SUMO1
orthologousEvent	[Reaction:R-CEL-4546386] PIAS1,3 SUMOylates NR5A1 with SUMO1 - Caenorhabditis elegans [Reaction:R-GGA-4546386] PIAS1,3 SUMOylates NR5A1 with SUMO1 - Gallus gallus [Reaction:R-DRE-4546386] PIAS1,3 SUMOylates NR5A1 with SUMO1 - Danio rerio [Reaction:R-SSC-4546386] PIAS1,3 SUMOylates NR5A1 with SUMO1 - Sus scrofa [Reaction:R-BTA-4546386] PIAS1,3 SUMOylates NR5A1 with SUMO1 - Bos taurus [Reaction:R-RNO-4546386] PIAS1,3 SUMOylates NR5A1 with SUMO1 - Rattus norvegicus [Reaction:R-MMU-4546386] PIAS1,3 SUMOylates NR5A1 with SUMO1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-4546382] monoSUMO1-K119,K194-NR5A1 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4546386
summation	[Summation:4546345] PIAS1,3 SUMOylate NR5A1 (Steroidogenic factor 1, SF1, SF-1) ...
updateTrackers	[UpdateTracker:9775249] Update Tracker - [Reaction:4546386] PIAS1,3 SUMOylates NR5A1 with SUMO1 - v80:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9775249] Update Tracker - [Reaction:4546386] PIAS1,3 SUMOylates NR5A1 with SUMO1 - v80:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-4090294] SUMOylation of intracellular receptors