Reactome | Fatty acid ligands activate PPARA

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Fatty acid ligands activate PPARA Show undefined attributes

authored	[InstanceEdit:422414] May, B, 2009-05-30 16:45:51
catalystActivity	[CatalystActivity:9960249] nuclear receptor activity of PPARA:RXRA:Corepressors [nucleoplasm]
category	uncertain
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:400195] May, B, 2009-03-24 02:23:25
dbId	400143
displayName	Fatty acid ligands activate PPARA
edited	[InstanceEdit:422414] May, B, 2009-05-30 16:45:51 [InstanceEdit:425907] May, B, 2009-06-08
eventOf	[Pathway:R-HSA-400206] Regulation of lipid metabolism by PPARalpha - Homo sapiens [Pathway:R-HSA-9707564] Cytoprotection by HMOX1 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1989745] Expression of ACADM - Homo sapiens [BlackBoxEvent:R-HSA-1989747] Expression of FHL2 - Homo sapiens [BlackBoxEvent:R-HSA-1989749] Expression of ACOX1 - Homo sapiens [BlackBoxEvent:R-HSA-1989748] Expression of GRHL1 - Homo sapiens [BlackBoxEvent:R-HSA-1989751] Expression of FABP1 - Homo sapiens [BlackBoxEvent:R-HSA-1989750] Expression of FATP1 (SLC27A1) - Homo sapiens [BlackBoxEvent:R-HSA-1989753] Expression of PEX11A - Homo sapiens [BlackBoxEvent:R-HSA-1989752] Expression of TXNRD1 - Homo sapiens [BlackBoxEvent:R-HSA-1989755] Expression of CYP4A11 - Homo sapiens [BlackBoxEvent:R-HSA-1989754] Expression of APOA1 - Homo sapiens [BlackBoxEvent:R-HSA-1989757] Expression of FADS1 - Homo sapiens [BlackBoxEvent:R-HSA-1989759] Expression of G0S2 - Homo sapiens [BlackBoxEvent:R-HSA-1989758] Expression of UGT1A9 - Homo sapiens [BlackBoxEvent:R-HSA-1989761] Expression of APOA5 - Homo sapiens [BlackBoxEvent:R-HSA-1989760] Expression of HMGCS2 - Homo sapiens [BlackBoxEvent:R-HSA-1989762] Expression of ABCB4 - Homo sapiens [BlackBoxEvent:R-HSA-1989765] Expression of ABCA1 - Homo sapiens [BlackBoxEvent:R-HSA-1989764] Expression of CYP1A1 - Homo sapiens [BlackBoxEvent:R-HSA-1989767] Expression of TRIB3 - Homo sapiens [BlackBoxEvent:R-HSA-1989768] Expression of TIAM2 - Homo sapiens [BlackBoxEvent:R-HSA-1989771] Expression of TNFRSF21 - Homo sapiens [BlackBoxEvent:R-HSA-1989770] Expression of PLIN2 - Homo sapiens [BlackBoxEvent:R-HSA-1989773] Expression of CPT2 - Homo sapiens [BlackBoxEvent:R-HSA-1989772] Expression of GLIPR1 - Homo sapiens [BlackBoxEvent:R-HSA-1989775] Expression of SULT2A1 - Homo sapiens [BlackBoxEvent:R-HSA-1989777] Expression of RGL1 - Homo sapiens [BlackBoxEvent:R-HSA-1989776] Expression of APOA2 - Homo sapiens [BlackBoxEvent:R-HSA-1989779] Expression of ANKRD1 - Homo sapiens [BlackBoxEvent:R-HSA-1989778] Expression of ACSL1 - Homo sapiens [BlackBoxEvent:R-HSA-1655850] Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) - Homo sapiens [BlackBoxEvent:R-HSA-1655848] Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) - Homo sapiens [BlackBoxEvent:R-HSA-1655826] Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) - Homo sapiens [BlackBoxEvent:R-HSA-560517] Expression of CD36 (platelet glycoprotein IV, FAT) - Homo sapiens [BlackBoxEvent:R-HSA-1989774] Expression of AGT - Homo sapiens [BlackBoxEvent:R-HSA-1989756] Expression of ME1 - Homo sapiens [BlackBoxEvent:R-HSA-1989766] Expression of CTGF - Homo sapiens [BlackBoxEvent:R-HSA-400183] PPARA:RXRA binds Corepressors of PPARA - Homo sapiens [BlackBoxEvent:R-HSA-1592238] Expression of ALAS1 - Homo sapiens [BlackBoxEvent:R-HSA-1989746] Expression of CYP7A1 - Homo sapiens [BlackBoxEvent:R-HSA-560473] Expression of ANGPTL4 - Homo sapiens [BlackBoxEvent:R-HSA-1801587] Expression of Carnitine O-palmitoyltransferase 1 CPT1A - Homo sapiens [BlackBoxEvent:R-HSA-879724] Expression of PPARA - Homo sapiens [BlackBoxEvent:R-HSA-1368065] RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17788] positive regulation of transcription by RNA polymerase II
input	[DefinedSet:R-HSA-400216] Coactivators of PPARalpha [nucleoplasm] [Complex:R-HSA-2026984] FABP1:ligands of PPARA [nucleoplasm] [Complex:R-HSA-400196] PPARA:RXRA:Corepressors [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:400106] From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions [LiteratureReference:400147] Peroxisome proliferator activated receptors and lipoprotein metabolism [LiteratureReference:400187] Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis [LiteratureReference:400127] Peroxisome proliferator-activated receptors: nuclear control of metabolism [LiteratureReference:400178] Transcription coactivators for peroxisome proliferator-activated receptors [LiteratureReference:400156] Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay [LiteratureReference:400108] Selectivity of fatty acid ligands for PPARalpha which correlates both with binding to cis-element and DNA binding-independent transactivity in Caco-2 cells [LiteratureReference:400211] Peroxisome proliferator-activated receptors, coactivators, and downstream targets [LiteratureReference:383069] A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors [LiteratureReference:1989677] L-FABP directly interacts with PPARalpha in cultured primary hepatocytes [LiteratureReference:1989734] Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus [LiteratureReference:9709896] Bilirubin Binding to PPAR? Inhibits Lipid Accumulation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Fatty acid ligands activate PPARA
orthologousEvent	[BlackBoxEvent:R-MMU-400143] Fatty acid ligands activate PPARA - Mus musculus [BlackBoxEvent:R-RNO-400143] Fatty acid ligands activate PPARA - Rattus norvegicus [BlackBoxEvent:R-CFA-400143] Fatty acid ligands activate PPARA - Canis familiaris [BlackBoxEvent:R-BTA-400143] Fatty acid ligands activate PPARA - Bos taurus [BlackBoxEvent:R-DRE-400143] Fatty acid ligands activate PPARA - Danio rerio [BlackBoxEvent:R-DME-400143] Fatty acid ligands activate PPARA - Drosophila melanogaster
output	[DefinedSet:R-HSA-400207] Corepressors of PPARalpha [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1989743] FABP1 [nucleoplasm] [Complex:R-HSA-400154] PPARA:RXRA Coactivator complex [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-400183] PPARA:RXRA binds Corepressors of PPARA - Homo sapiens [Reaction:R-HSA-2026996] FABP1 transports fatty acids into the nucleus - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:425906] Kersten, S, 2009-06-08 [InstanceEdit:9713327] Somers, Julia, 2021-01-23 [InstanceEdit:9963235] Hill, David P, 2025-08-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-400143
summation	[Summation:400148] PPAR-alpha is activated by binding polyunsaturated fatty aci...
updateTrackers	[UpdateTracker:9964623] Update Tracker - [BlackBoxEvent:400143] Fatty acid ligands activate PPARA - v94:[modifyText, removeCatalystActivity] [UpdateTracker:9776358] Update Tracker - [Reaction:400143] Fatty acid ligands activate PPARA - v76:[addLiteratureReference, modifyText] [UpdateTracker:9788841] Update Tracker - [Reaction:400143] Fatty acid ligands activate PPARA - v40:[addLiteratureReference, addOutput, add_removeInput]

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-1592238] Expression of ALAS1 [BlackBoxEvent:R-HSA-1989745] Expression of ACADM [BlackBoxEvent:R-HSA-1989747] Expression of FHL2 [BlackBoxEvent:R-HSA-1989746] Expression of CYP7A1 [BlackBoxEvent:R-HSA-1989749] Expression of ACOX1 [BlackBoxEvent:R-HSA-1989748] Expression of GRHL1 [BlackBoxEvent:R-HSA-1989751] Expression of FABP1 [BlackBoxEvent:R-HSA-1989750] Expression of FATP1 (SLC27A1) [BlackBoxEvent:R-HSA-1989753] Expression of PEX11A [BlackBoxEvent:R-HSA-1989752] Expression of TXNRD1 [BlackBoxEvent:R-HSA-1989755] Expression of CYP4A11 [BlackBoxEvent:R-HSA-1989754] Expression of APOA1 [BlackBoxEvent:R-HSA-1989757] Expression of FADS1 [BlackBoxEvent:R-HSA-1989759] Expression of G0S2 [BlackBoxEvent:R-HSA-1989758] Expression of UGT1A9 [BlackBoxEvent:R-HSA-1989761] Expression of APOA5 [BlackBoxEvent:R-HSA-1989760] Expression of HMGCS2 [BlackBoxEvent:R-HSA-1989762] Expression of ABCB4 [BlackBoxEvent:R-HSA-1989765] Expression of ABCA1 [BlackBoxEvent:R-HSA-1989764] Expression of CYP1A1 [BlackBoxEvent:R-HSA-1989767] Expression of TRIB3 [BlackBoxEvent:R-HSA-1989768] Expression of TIAM2 [BlackBoxEvent:R-HSA-1989771] Expression of TNFRSF21 [BlackBoxEvent:R-HSA-1989770] Expression of PLIN2 [BlackBoxEvent:R-HSA-1989773] Expression of CPT2 [BlackBoxEvent:R-HSA-1989772] Expression of GLIPR1 [BlackBoxEvent:R-HSA-1989775] Expression of SULT2A1 [BlackBoxEvent:R-HSA-1989777] Expression of RGL1 [BlackBoxEvent:R-HSA-1989776] Expression of APOA2 [BlackBoxEvent:R-HSA-1989779] Expression of ANKRD1 [BlackBoxEvent:R-HSA-1989778] Expression of ACSL1 [BlackBoxEvent:R-HSA-1655850] Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) [BlackBoxEvent:R-HSA-1655848] Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) [BlackBoxEvent:R-HSA-1655826] Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) [BlackBoxEvent:R-HSA-560473] Expression of ANGPTL4 [BlackBoxEvent:R-HSA-560517] Expression of CD36 (platelet glycoprotein IV, FAT) [BlackBoxEvent:R-HSA-1801587] Expression of Carnitine O-palmitoyltransferase 1 CPT1A [BlackBoxEvent:R-HSA-400183] PPARA:RXRA binds Corepressors of PPARA [BlackBoxEvent:R-HSA-879724] Expression of PPARA [BlackBoxEvent:R-HSA-1989774] Expression of AGT [BlackBoxEvent:R-HSA-1989756] Expression of ME1 [BlackBoxEvent:R-HSA-1368065] RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2 [BlackBoxEvent:R-HSA-1989766] Expression of CTGF
(hasEvent)	[Pathway:R-HSA-400206] Regulation of lipid metabolism by PPARalpha [Pathway:R-HSA-9707564] Cytoprotection by HMOX1
(updatedInstance)	[UpdateTracker:9964623] Update Tracker - [BlackBoxEvent:400143] Fatty acid ligands activate PPARA - v94:[modifyText, removeCatalystActivity] [UpdateTracker:9776358] Update Tracker - [Reaction:400143] Fatty acid ligands activate PPARA - v76:[addLiteratureReference, modifyText] [UpdateTracker:9788841] Update Tracker - [Reaction:400143] Fatty acid ligands activate PPARA - v40:[addLiteratureReference, addOutput, add_removeInput]

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