Reactome | Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)

Schema > BlackBoxEvent > Entries

Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) Show undefined attributes

authored	[InstanceEdit:1655770] May, B, 2011-09-28
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1655841] May, B, 2011-10-13
dbId	1655850
displayName	Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)
edited	[InstanceEdit:1655770] May, B, 2011-09-28
eventOf	[Pathway:R-HSA-1989781] PPARA activates gene expression - Homo sapiens [Pathway:R-HSA-2426168] Activation of gene expression by SREBF (SREBP) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17788] positive regulation of transcription by RNA polymerase II
input	[EntityWithAccessionedSequence:R-HSA-2393991] FDFT1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1660630] Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase
maxDepth	1
modified	[InstanceEdit:9961204] D'Eustachio, Peter, 2025-07-21
name	Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)
output	[EntityWithAccessionedSequence:R-HSA-191369] FDFT1 [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-HSA-400143] Fatty acid ligands activate PPARA - Homo sapiens [Reaction:R-HSA-2426146] SREBP1A,1C,2 binds the FDFT1 promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-1989809] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5649959] Positive gene expression regulation by 'SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9641911] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]' Profiling of promoter occupancy by PPAR{alpha} in human hepatoma cells via ChIP-chip analysis [RegulationReference:9643034] Positive gene expression regulation by 'SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm]' Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:425906] Kersten, S, 2009-06-08 [InstanceEdit:2457630] Liang, Guosheng, 2012-08-25
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1655850
summation	[Summation:1655775] The FDFT1 gene is transcribed to yield mRNA and the mRNA is ...
updateTrackers	[UpdateTracker:9786413] Update Tracker - [BlackBoxEvent:1655850] Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) - v49:[removeRegulator] [UpdateTracker:9784999] Update Tracker - [BlackBoxEvent:1655850] Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) - v52:[addRegulator, add_removeInput] [UpdateTracker:9788491] Update Tracker - [BlackBoxEvent:1655850] Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) - v42:[addInput, add_removeRegulator]

Referrals

(updatedInstance)

(hasEvent)

Cite Us!