Reactome | Cytoprotection by HMOX1

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Cytoprotection by HMOX1 Show undefined attributes

authored	[InstanceEdit:9707640] Stephan, Ralf, 2020-11-12
created	[InstanceEdit:9707568] Stephan, Ralf, 2020-11-19
dbId	9707564
displayName	Cytoprotection by HMOX1
edited	[InstanceEdit:9707640] Stephan, Ralf, 2020-11-12
eventOf	[Pathway:R-HSA-9711123] Cellular response to chemical stress - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:376615] cellular response to oxidative stress
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-9707587] Regulation of HMOX1 expression and activity - Homo sapiens [Reaction:R-HSA-1250272] TXNIP binds NLRP3 - Homo sapiens [Reaction:R-HSA-9709918] PTK6 phosphorylates STAT3 - Homo sapiens [Reaction:R-HSA-189398] HMOX1 dimer, HMOX2 cleave heme - Homo sapiens [Reaction:R-HSA-189384] BLVRA:Zn2+, BLVRB reduce BV to BIL - Homo sapiens [BlackBoxEvent:R-HSA-9709366] CO translocates from cytosol to mitochondrial inner membrane - Homo sapiens [Reaction:R-HSA-9709406] CO binds to Cytochrome c oxidase - Homo sapiens [Reaction:R-HSA-163214] Electron transfer from reduced cytochrome c to molecular oxygen - Homo sapiens [BlackBoxEvent:R-HSA-9709396] CO translocates from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-9709317] CO binds to free ferrohemoglobin - Homo sapiens [Reaction:R-HSA-9707504] H2O2 oxidises ferrohemoglobin to MetHb - Homo sapiens [Reaction:R-HSA-9709360] H2O2 reduces MetHb - Homo sapiens [BlackBoxEvent:R-HSA-9709879] BIL scavenges O2.- - Homo sapiens [Reaction:R-HSA-9661405] ABCC1 transports BIL from cytosol to extracellular region (blood) - Homo sapiens [Reaction:R-HSA-9661432] BIL binds ALB - Homo sapiens [BlackBoxEvent:R-HSA-9709883] BIL:ALB scavenges O2.- - Homo sapiens [Reaction:R-HSA-9709885] BIL scavenges NO - Homo sapiens [BlackBoxEvent:R-HSA-9709878] BIL translocates to the nucleus - Homo sapiens [BlackBoxEvent:R-HSA-400143] Fatty acid ligands activate PPARA - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:9708926] Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury [LiteratureReference:9709924] Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease [LiteratureReference:9708949] Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications [LiteratureReference:9709889] The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance [LiteratureReference:9709910] Bilirubin, a Cardiometabolic Signaling Molecule
maxDepth	3
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Cytoprotection by HMOX1
orthologousEvent	[Pathway:R-MMU-9707564] Cytoprotection by HMOX1 - Mus musculus [Pathway:R-RNO-9707564] Cytoprotection by HMOX1 - Rattus norvegicus [Pathway:R-CFA-9707564] Cytoprotection by HMOX1 - Canis familiaris [Pathway:R-BTA-9707564] Cytoprotection by HMOX1 - Bos taurus [Pathway:R-SSC-9707564] Cytoprotection by HMOX1 - Sus scrofa [Pathway:R-DRE-9707564] Cytoprotection by HMOX1 - Danio rerio [Pathway:R-XTR-9707564] Cytoprotection by HMOX1 - Xenopus tropicalis [Pathway:R-GGA-9707564] Cytoprotection by HMOX1 - Gallus gallus [Pathway:R-DME-9707564] Cytoprotection by HMOX1 - Drosophila melanogaster [Pathway:R-DDI-9707564] Cytoprotection by HMOX1 - Dictyostelium discoideum [Pathway:R-SPO-9707564] Cytoprotection by HMOX1 - Schizosaccharomyces pombe [Pathway:R-SCE-9707564] Cytoprotection by HMOX1 - Saccharomyces cerevisiae
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9713327] Somers, Julia, 2021-01-23 [InstanceEdit:9956890] Hill, David P, 2025-06-16 [InstanceEdit:9960546] Matthews, Lisa, 2025-07-14
revised	[InstanceEdit:9766710] Rothfels, Karen, 2022-02-23
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9707564
summation	[Summation:9709923] Expression of heme oxygenase 1 (HMOX1) is regulated by vario...
updateTrackers	[UpdateTracker:9911050] Update Tracker - [Pathway:9707564] Cytoprotection by HMOX1 - v89:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9774858] Update Tracker - [Pathway:9707564] Cytoprotection by HMOX1 - v80:[updateContainedPathway, updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-9711123] Cellular response to chemical stress
(hasEncapsulatedEvent)	[Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes
(updatedInstance)	[UpdateTracker:9911050] Update Tracker - [Pathway:9707564] Cytoprotection by HMOX1 - v89:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9774858] Update Tracker - [Pathway:9707564] Cytoprotection by HMOX1 - v80:[updateContainedPathway, updateIndirectRLE]

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