RHOA propagates downstream signals by binding to effector proteins such as Rho-associated, coiled-coil containing protein kinases (ROCKs). ROCKs consist of an amino-terminal kinase domain, followed by a Rho-binding domain (RBD) and a carboxy terminal cysteine-rich domain (CRD) located within the pleckstrin homology (PH) motif. RHOA:GTP interacts with the RBD domain and activates the phosphotransferase activity (Ishizaki et al. 1996, Amano et al. 2000).
Heat-shock protein of 90 kDa (HSP90) recruited to VEGFR2 initiates the activation of Rho-dependent kinase (ROCK) (Le Boeuf et al. 2004, 2006).
Li, Y, Marto, JA, Song, HK, Gould, CJ, Ficarro, SB, Tu, D, Eck, MJ, Goode, BL, Toms, AV
Saito, Y, Fujita, A, Narumiya, S, Okawa, K, Iwamatsu, A, Morii, N, Fujisawa, K, Kakizuka, A, Ishizaki, T, Watanabe, N, Maekawa, M
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