Reactome | RHOA:GTP:Mg2+ binds ROCK1,ROCK2

RHOA:GTP:Mg2+ binds ROCK1,ROCK2

Stable Identifier

R-HSA-3928647

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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RHOA propagates downstream signals by binding to effector proteins such as Rho-associated, coiled-coil containing protein kinases (ROCKs). ROCKs consist of an amino-terminal kinase domain, followed by a Rho-binding domain (RBD) and a carboxy terminal cysteine-rich domain (CRD) located within the pleckstrin homology (PH) motif. RHOA:GTP interacts with the RBD domain and activates the phosphotransferase activity (Ishizaki et al. 1996, Amano et al. 2000). Heat-shock protein of 90 kDa (HSP90) recruited to VEGFR2 initiates the activation of Rho-dependent kinase (ROCK) (Le Boeuf et al. 2004, 2006).

Literature References

PubMed ID	Title	Journal	Year
21445309	Crystal structure of a coiled-coil domain from human ROCK I Tu, D, Li, Y, Song, HK, Toms, AV, Gould, CJ, Ficarro, SB, Marto, JA, Goode, BL, Eck, MJ	PLoS ONE	2011
8617235	The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase Ishizaki, T, Maekawa, M, Fujisawa, K, Okawa, K, Iwamatsu, A, Fujita, A, Watanabe, N, Saito, Y, Kakizuka, A, Morii, N, Narumiya, S	EMBO J	1996