Reactome | RHOA propagates downstream signals by binding to effector pr...

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created	[InstanceEdit:3928288] Garapati, P V, 2013-07-22
dbId	3928307
displayName	RHOA propagates downstream signals by binding to effector pr...
literatureReference	[LiteratureReference:3927978] Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease [LiteratureReference:3927998] Regulation and functions of Rho-associated kinase [LiteratureReference:421378] The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase
modified	[InstanceEdit:5228988] Garapati, P V, 2014-01-15
schemaClass	Summation
text	RHOA propagates downstream signals by binding to effector proteins such as Rho-associated, coiled-coil containing protein kinases (ROCKs). ROCKs consist of an amino-terminal kinase domain, followed by a Rho-binding domain (RBD) and a carboxy terminal cysteine-rich domain (CRD) located within the pleckstrin homology (PH) motif. RHOA:GTP interacts with the RBD domain and activates the phosphotransferase activity (Ishizaki et al. 1996, Amano et al. 2000).

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