Reactome | G alpha (z) inhibits adenylate cyclase

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G alpha (z) inhibits adenylate cyclase Show undefined attributes

authored	[InstanceEdit:391990] Jupe, S, 2009-02-26 14:43:12
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:392065] Jupe, S, 2009-02-26 17:47:01
dbId	392064
displayName	G alpha (z) inhibits adenylate cyclase
edited	[InstanceEdit:435382] Jupe, S, 2009-09-09
eventOf	[Pathway:R-HSA-418597] G alpha (z) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - Homo sapiens
input	[Complex:R-HSA-170665] Adenylate cyclase (Mg2+ cofactor) [plasma membrane] [Complex:R-HSA-392003] G-protein alpha (z):GTP [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:435198] Activation of type II adenylyl cyclase by the cloned mu-opioid receptor: coupling to multiple G proteins [LiteratureReference:435195] Gz-mediated hormonal inhibition of cyclic AMP accumulation
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	G alpha (z) inhibits adenylate cyclase
orthologousEvent	[Reaction:R-DDI-392064] G alpha (z) inhibits adenylate cyclase - Dictyostelium discoideum [Reaction:R-CEL-392064] G alpha (z) inhibits adenylate cyclase - Caenorhabditis elegans [Reaction:R-DME-392064] G alpha (z) inhibits adenylate cyclase - Drosophila melanogaster [Reaction:R-GGA-392064] G alpha (z) inhibits adenylate cyclase - Gallus gallus [Reaction:R-XTR-392064] G alpha (z) inhibits adenylate cyclase - Xenopus tropicalis [Reaction:R-DRE-392064] G alpha (z) inhibits adenylate cyclase - Danio rerio [Reaction:R-SSC-392064] G alpha (z) inhibits adenylate cyclase - Sus scrofa [Reaction:R-BTA-392064] G alpha (z) inhibits adenylate cyclase - Bos taurus [Reaction:R-CFA-392064] G alpha (z) inhibits adenylate cyclase - Canis familiaris [Reaction:R-RNO-392064] G alpha (z) inhibits adenylate cyclase - Rattus norvegicus [Reaction:R-MMU-392064] G alpha (z) inhibits adenylate cyclase - Mus musculus
output	[Complex:R-HSA-392049] G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane]
precedingEvent	[Reaction:R-HSA-380073] Liganded Gi-activating GPCR acts as a GEF for Gi - Homo sapiens [Reaction:R-HSA-751024] The Ligand:GPCR:Gz complex dissociates - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-392064
summation	[Summation:400698] G-proteins in the Gi class inhibit adenylate cyclase activit...
updateTrackers	[UpdateTracker:9791247] Update Tracker - [Reaction:392064] G alpha (z) inhibits adenylate cyclase - v31:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791247] Update Tracker - [Reaction:392064] G alpha (z) inhibits adenylate cyclase - v31:[modifyText]
(hasEvent)	[Pathway:R-HSA-418597] G alpha (z) signalling events
(precedingEvent)	[Reaction:R-HSA-392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate