Reactome | Activation of Vav1

Schema > Reaction > Entries

Activation of Vav1 Show undefined attributes

authored	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
catalystActivity	[CatalystActivity:9038308] protein tyrosine kinase activity of FYN [cytosol]
catalystActivityReference	[CatalystActivityReference:9643895] protein tyrosine kinase activity of FYN [cytosol] Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:389353] Garapati, P V, 2009-01-06 13:42:50
dbId	389354
displayName	Activation of Vav1
edited	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
eventOf	[Pathway:R-HSA-389359] CD28 dependent Vav1 pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-389350] Activation of Cdc42 by pVav1 - Homo sapiens [Reaction:R-HSA-389348] Activation of Rac1 by pVav1 - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-389334] VAV1:PIP3:CD28:GRB2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:389278] Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells [LiteratureReference:389267] Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription [LiteratureReference:389268] Vav-family proteins in T-cell signalling [LiteratureReference:389276] Vav1: a key signal transducer downstream of the TCR
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activation of Vav1
orthologousEvent	[Reaction:R-MMU-389354] Activation of Vav1 - Mus musculus [Reaction:R-GGA-389354] Activation of Vav1 - Gallus gallus [Reaction:R-XTR-389354] Activation of Vav1 - Xenopus tropicalis [Reaction:R-SSC-389354] Activation of Vav1 - Sus scrofa [Reaction:R-BTA-389354] Activation of Vav1 - Bos taurus [Reaction:R-CFA-389354] Activation of Vav1 - Canis familiaris [Reaction:R-RNO-389354] Activation of Vav1 - Rattus norvegicus
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-389332] p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-389352] Translocation of Vav1 to CD28 - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-389354
summation	[Summation:389275] Vav1 exists in an auto-inhibitory state folded in such a way...
updateTrackers	[UpdateTracker:9779789] Update Tracker - [Reaction:389354] Activation of Vav1 - v64:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9779789] Update Tracker - [Reaction:389354] Activation of Vav1 - v64:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-389359] CD28 dependent Vav1 pathway
(precedingEvent)	[Reaction:R-HSA-389350] Activation of Cdc42 by pVav1 [Reaction:R-HSA-389348] Activation of Rac1 by pVav1