Reactome | Translocation of Vav1 to CD28

Translocation of Vav1 to CD28

Stable Identifier

R-HSA-389352

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Vav1 protein is a cytoplasmic guanine nucleotide exchange factor (GEF) for Rho-family GTPases. CD28 co-stimulation resulted in a prolonged and sustained phosphorylation and membrane localization of Vav1 in comparison to T-cell receptor activation alone. Vav1 contains a unique arrangement of signaling motifs a calponin homology domain, an acidic domain, a DBL homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich domain (CR), and a SH2 domain flanked by two proline-binding SH3 domains. Vav-1 may be recruited to the membrane through its PH domain by binding PI(3,4,5)P3 produced by CD28-bound PI3K and also by binding to CD28:Grb2 complexes by the dimerized SH3 domains in both the molecules.

Literature References

PubMed ID	Title	Journal	Year
10849438	Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription Hehner, SP, Hofmann, TG, Dienz, O, Droge, W, Schmitz, ML	J Biol Chem	2000
18295596	CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription Schneider, H, Rudd, CE	Biochem Biophys Res Commun	2008
15886116	Vav-family proteins in T-cell signalling Tybulewicz, VL	Curr Opin Immunol	2005