Reactome | Activation of Cdc42 by pVav1

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Activation of Cdc42 by pVav1 Show undefined attributes

authored	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
catalystActivity	[CatalystActivity:389351] guanyl-nucleotide exchange factor activity of p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:389353] Garapati, P V, 2009-01-06 13:42:50
dbId	389350
displayName	Activation of Cdc42 by pVav1
edited	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
eventOf	[Pathway:R-HSA-389359] CD28 dependent Vav1 pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-389788] Activation of PAKs by RAC1 and CDC42 - Homo sapiens [Reaction:R-HSA-8981931] RAC1 and CDC42 activate PAK2 - Homo sapiens [Reaction:R-HSA-8981926] RAC1 and CDC42 activate PAK3 - Homo sapiens
input	[Complex:R-HSA-418830] CDC42:GDP [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:389302] Lck regulates Vav activation of members of the Rho family of GTPases
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activation of Cdc42 by pVav1
orthologousEvent	[Reaction:R-MMU-389350] Activation of Cdc42 by pVav1 - Mus musculus [Reaction:R-GGA-389350] Activation of Cdc42 by pVav1 - Gallus gallus [Reaction:R-XTR-389350] Activation of Cdc42 by pVav1 - Xenopus tropicalis [Reaction:R-SSC-389350] Activation of Cdc42 by pVav1 - Sus scrofa [Reaction:R-BTA-389350] Activation of Cdc42 by pVav1 - Bos taurus [Reaction:R-CFA-389350] Activation of Cdc42 by pVav1 - Canis familiaris [Reaction:R-RNO-389350] Activation of Cdc42 by pVav1 - Rattus norvegicus
output	[Complex:R-HSA-182921] CDC42:GTP [plasma membrane] [SimpleEntity:R-ALL-29420] GDP [cytosol]
precedingEvent	[Reaction:R-HSA-389354] Activation of Vav1 - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-389350
summation	[Summation:389296] Vav1 functions as a guanine nucleotide exchange factor (GEF)...
updateTrackers	[UpdateTracker:9928492] Update Tracker - [Reaction:389350] Activation of Cdc42 by pVav1 - v91:[modifyText] [UpdateTracker:9791055] Update Tracker - [Reaction:389350] Activation of Cdc42 by pVav1 - v32:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9928492] Update Tracker - [Reaction:389350] Activation of Cdc42 by pVav1 - v91:[modifyText] [UpdateTracker:9791055] Update Tracker - [Reaction:389350] Activation of Cdc42 by pVav1 - v32:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-389359] CD28 dependent Vav1 pathway
(precedingEvent)	[Reaction:R-HSA-389788] Activation of PAKs by RAC1 and CDC42 [Reaction:R-HSA-8981931] RAC1 and CDC42 activate PAK2 [Reaction:R-HSA-8981926] RAC1 and CDC42 activate PAK3