Reactome | Activation of Cdc42 by pVav1

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Activation of Cdc42 by pVav1 Show undefined attributes

catalystActivity	[CatalystActivity:10671675] guanyl-nucleotide exchange factor activity of p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10671677
displayName	Activation of Cdc42 by pVav1
eventOf	[Pathway:R-XTR-389359] CD28 dependent Vav1 pathway - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-389788] Activation of PAKs by RAC1 and CDC42 - Xenopus tropicalis [Reaction:R-XTR-8981931] RAC1 and CDC42 activate PAK2 - Xenopus tropicalis [Reaction:R-XTR-8981926] RAC1 and CDC42 activate PAK3 - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-389350] Activation of Cdc42 by pVav1 - Homo sapiens
input	[Complex:R-XTR-418830] CDC42:GDP [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of Cdc42 by pVav1
output	[Complex:R-XTR-182921] CDC42:GTP [plasma membrane] [SimpleEntity:R-ALL-29420] GDP [cytosol]
precedingEvent	[Reaction:R-XTR-389354] Activation of Vav1 - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-389350
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-389359] CD28 dependent Vav1 pathway
(precedingEvent)	[Reaction:R-XTR-389788] Activation of PAKs by RAC1 and CDC42 [Reaction:R-XTR-8981931] RAC1 and CDC42 activate PAK2 [Reaction:R-XTR-8981926] RAC1 and CDC42 activate PAK3
(inferredTo)	[Reaction:R-HSA-389350] Activation of Cdc42 by pVav1