Reactome | RAC1 and CDC42 activate PAK3

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RAC1 and CDC42 activate PAK3 Show undefined attributes

authored	[InstanceEdit:373757] Garapati, P V, 2008-07-16 14:42:16
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8981930] Orlic-Milacic, Marija, 2017-03-15
dbId	8981926
displayName	RAC1 and CDC42 activate PAK3
edited	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
eventOf	[Pathway:R-HSA-5627123] RHO GTPases activate PAKs - Homo sapiens
followingEvent	[Reaction:R-HSA-5627775] Autophosphorylation of PAK1,2,3 - Homo sapiens
input	[DefinedSet:R-HSA-389778] CDC42:GTP, RAC1:GTP [plasma membrane] [Complex:R-HSA-5669154] PAK3 dimer [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:389773] p21-activated protein kinase: a crucial component of morphological signaling? [LiteratureReference:434953] Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements [LiteratureReference:442649] A brain serine/threonine protein kinase activated by Cdc42 and Rac1 [LiteratureReference:5628821] Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family [LiteratureReference:5628823] Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA [LiteratureReference:5627780] Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch [LiteratureReference:2028849] Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	RAC1 and CDC42 activate PAK3
orthologousEvent	[Reaction:R-MMU-8981926] RAC1 and CDC42 activate PAK3 - Mus musculus [Reaction:R-SCE-8981926] RAC1 and CDC42 activate PAK3 - Saccharomyces cerevisiae [Reaction:R-SPO-8981926] RAC1 and CDC42 activate PAK3 - Schizosaccharomyces pombe [Reaction:R-DDI-8981926] RAC1 and CDC42 activate PAK3 - Dictyostelium discoideum [Reaction:R-CEL-8981926] RAC1 and CDC42 activate PAK3 - Caenorhabditis elegans [Reaction:R-DME-8981926] RAC1 and CDC42 activate PAK3 - Drosophila melanogaster [Reaction:R-GGA-8981926] RAC1 and CDC42 activate PAK3 - Gallus gallus [Reaction:R-XTR-8981926] RAC1 and CDC42 activate PAK3 - Xenopus tropicalis [Reaction:R-BTA-8981926] RAC1 and CDC42 activate PAK3 - Bos taurus [Reaction:R-CFA-8981926] RAC1 and CDC42 activate PAK3 - Canis familiaris [Reaction:R-RNO-8981926] RAC1 and CDC42 activate PAK3 - Rattus norvegicus
output	[Complex:R-HSA-8981928] CDC42:GTP,RAC1:GTP:PAK3 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-428457] PAK3 [cytosol]
precedingEvent	[Reaction:R-HSA-389348] Activation of Rac1 by pVav1 - Homo sapiens [Reaction:R-HSA-389350] Activation of Cdc42 by pVav1 - Homo sapiens [Reaction:R-HSA-418850] Activation of Cdc42 - Homo sapiens [Reaction:R-HSA-418856] Activation of Rac1 - Homo sapiens [Reaction:R-HSA-8848618] Activation of RAC1 by the PXN:CRK complex - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8981926
summation	[Summation:8981929] Inactive p21-associated kinases (PAKs), PAK1, PAK2 and PAK3,...

Referrals

(hasEvent)	[Pathway:R-HSA-5627123] RHO GTPases activate PAKs
(precedingEvent)	[Reaction:R-HSA-5627775] Autophosphorylation of PAK1,2,3

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