Activation of Cdc42 by pVav1

Stable Identifier
R-HSA-389350
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Vav1 serves as a GEF for Cdc42-GTPase. It interacts with and activates Cdc42. The activated Cdc42 in turn transmits its signals through the downstream target, the PAK1 kinase.

Literature References
PubMed ID Title Journal Year
9032261 Lck regulates Vav activation of members of the Rho family of GTPases

Han, J, Das, B, Wei, W, Van Aelst, L, Mosteller, RD, Khosravi-Far, R, Westwick, JK, Der, CJ, Broek, D

Mol Cell Biol 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created