Activation of Cdc42 by pVav1

Stable Identifier
R-HSA-389350
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activation of Cdc42 by pVav1
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Vav1 serves as a GEF for Cdc42-GTPase. It interacts with and activates Cdc42. The activated Cdc42 in turn transmits its signals through the downstream target, the PAK1 kinase.

Literature References
PubMed ID Title Journal Year
9032261 Lck regulates Vav activation of members of the Rho family of GTPases

Westwick, JK, Der, CJ, Mosteller, RD, Wei, W, Han, J, Das, B, Broek, D, Khosravi-Far, R, Van Aelst, L

Mol Cell Biol 1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane]

Physical Entity
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
Activation of Cdc42 by pVav1 (Bos taurus)
Activation of Cdc42 by pVav1 (Canis familiaris)
Activation of Cdc42 by pVav1 (Danio rerio)
Activation of Cdc42 by pVav1 (Gallus gallus)
Activation of Cdc42 by pVav1 (Mus musculus)
Activation of Cdc42 by pVav1 (Rattus norvegicus)
Activation of Cdc42 by pVav1 (Sus scrofa)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2009-01-06)
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