Activation of Cdc42 by pVav1

Stable Identifier
R-HSA-389350
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activation of Cdc42 by pVav1
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Vav1 functions as a guanine nucleotide exchange factor (GEF) for Cdc42, facilitating its activation. Once activated, Cdc42 transmits its signals downstream to the PAK1 kinase, which plays a key role in regulating cytoskeletal dynamics and cell signaling. This Vav1-Cdc42-PAK1 signaling axis is crucial for processes like cell movement and immune responses (Tybulewicz 2005).
Literature References
PubMed ID Title Journal Year
9032261 Lck regulates Vav activation of members of the Rho family of GTPases

Han, J, Das, B, Wei, W, Van Aelst, L, Mosteller, RD, Khosravi-Far, R, Westwick, JK, Der, CJ, Broek, D

Mol Cell Biol 1997
Participants
Input
Output
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as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane]

Physical Entity
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
Activation of Cdc42 by pVav1 (Bos taurus)
Activation of Cdc42 by pVav1 (Canis familiaris)
Activation of Cdc42 by pVav1 (Gallus gallus)
Activation of Cdc42 by pVav1 (Mus musculus)
Activation of Cdc42 by pVav1 (Rattus norvegicus)
Activation of Cdc42 by pVav1 (Sus scrofa)
Activation of Cdc42 by pVav1 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2009-01-06)
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