Reactome | PPARG binds PPARG agonists

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PPARG binds PPARG agonists Show undefined attributes

authored	[InstanceEdit:9732664] Jassal, Bijay, 2021-05-28
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9732664] Jassal, Bijay, 2021-05-28
dbId	9732629
definition	Agonist\|Full agonist
displayName	PPARG binds PPARG agonists
edited	[InstanceEdit:9757169] Jassal, Bijay, 2021-10-27 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-381340] Transcriptional regulation of white adipocyte differentiation - Homo sapiens
input	[DefinedSet:R-ALL-9732650] PPARG agonists [nucleoplasm] [Complex:R-HSA-381226] PPARG:RXRA:Corepressor Complex [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9732648] N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents [LiteratureReference:9732662] Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma [LiteratureReference:9732612] Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	PPARG binds PPARG agonists
orthologousEvent	[Reaction:R-DME-9732629] PPARG binds PPARG agonists - Drosophila melanogaster [Reaction:R-GGA-9732629] PPARG binds PPARG agonists - Gallus gallus [Reaction:R-SSC-9732629] PPARG binds PPARG agonists - Sus scrofa [Reaction:R-BTA-9732629] PPARG binds PPARG agonists - Bos taurus [Reaction:R-CFA-9732629] PPARG binds PPARG agonists - Canis familiaris [Reaction:R-RNO-9732629] PPARG binds PPARG agonists - Rattus norvegicus [Reaction:R-MMU-9732629] PPARG binds PPARG agonists - Mus musculus
output	[Complex:R-HSA-9732600] PPARG:PPARG agonists [cytosol]
reactionType	[DrugActionType:9725061] Agonist
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9732629
summation	[Summation:9733254] Peroxisome proliferator-activated receptor gamma (PPARG) is ...

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[Pathway:R-HSA-381340] Transcriptional regulation of white adipocyte differentiation