Reactome | CHD4 [nucleoplasm]

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CHD4 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9976373] GATA3:CHD4:NuRD:TBX21 gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-9940447] ChAHP complex [nucleoplasm] - Homo sapiens [Complex:R-HSA-9613187] RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] - Homo sapiens [Complex:R-HSA-9613463] ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9976406] GATA3, CHD4, and the NuRD complex bind the TBX21 (T-BET) gene - Homo sapiens [Reaction:R-HSA-9976381] GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene - Homo sapiens [Reaction:R-HSA-9976129] GATA3, CHD4, EP300, NFATC2 (NFAT1), FOS:JUN (AP-1), KLF13, and MAF bind the IL4 gene - Homo sapiens [Reaction:R-HSA-9613213] NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression - Homo sapiens [Reaction:R-HSA-9940466] Formation of ChAHP2 complex - Homo sapiens [Reaction:R-HSA-9940477] Formation of ChAHP complex - Homo sapiens [Reaction:R-HSA-9613476] EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions - Homo sapiens
created	[InstanceEdit:3702076] Jupe, S, 2013-06-12
dbId	3702078
displayName	CHD4 [nucleoplasm]
endCoordinate	1912
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-3702078] CHD4 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-3702078] Chd4 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-3702078] CHD4 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-3702078] CHD4 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-3702078] CHD4 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-3702078] chd4b [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-GGA-3702078] CHD4 [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DME-3702078] CHD4 [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-3702078-2] CHD4 [nucleoplasm] - Drosophila melanogaster [DefinedSet:R-DME-3702078-3] Homologues of CHD4 [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-3702078] CHD4 [nucleoplasm] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-3702078-2] CHD4 [nucleoplasm] - Caenorhabditis elegans [DefinedSet:R-CEL-3702078-3] Homologues of CHD4 [nucleoplasm] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-SPO-3702078] CHD4 [nucleoplasm] - Schizosaccharomyces pombe
maxDepth	1
memberOf	[DefinedSet:R-HSA-4657021] Mi-2 [nucleoplasm] - Homo sapiens [DefinedSet:R-HSA-9940424] CHD3, CHD4, CHD5 [nucleoplasm] - Homo sapiens
name	CHD4 Chromodomain-helicase-DNA-binding protein 4 CHD4_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:Q14839] UniProt:Q14839 CHD4
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-3702078
startCoordinate	1

Referrals

(hasComponent)	[Complex:R-HSA-9976373] GATA3:CHD4:NuRD:TBX21 gene [nucleoplasm] [Complex:R-HSA-9976378] GATA3:CHD4:EP300:p-S243-NFATC2:IL13 gene [nucleoplasm] [Complex:R-HSA-9976142] GATA3:CHD4:EP300:p-S243-NFATC2:FOS:JUN:KLF13:MAF:IL4 gene [nucleoplasm] [Complex:R-HSA-9940447] ChAHP complex [nucleoplasm] [Complex:R-HSA-9940446] ChAHP2 complex [nucleoplasm] [Complex:R-HSA-9613463] ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] [Complex:R-HSA-9613187] RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm]
(input)	[Reaction:R-HSA-9976406] GATA3, CHD4, and the NuRD complex bind the TBX21 (T-BET) gene [Reaction:R-HSA-9976381] GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene [Reaction:R-HSA-9976129] GATA3, CHD4, EP300, NFATC2 (NFAT1), FOS:JUN (AP-1), KLF13, and MAF bind the IL4 gene [Reaction:R-HSA-9940477] Formation of ChAHP complex [Reaction:R-HSA-9940466] Formation of ChAHP2 complex [Reaction:R-HSA-9613476] EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions [Reaction:R-HSA-9613213] NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression
(hasMember)	[DefinedSet:R-HSA-9940424] CHD3, CHD4, CHD5 [nucleoplasm] [DefinedSet:R-HSA-4657021] Mi-2 [nucleoplasm]
(activeUnit)	[NegativeGeneExpressionRegulation:9613192] Negative gene expression regulation by 'RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm]'

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