Reactome | GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene

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GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene Show undefined attributes

authored	[InstanceEdit:9976368] May, Bruce, 2025-12-11
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9976404] May, Bruce, 2025-12-11
dbId	9976381
displayName	GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene
edited	[InstanceEdit:9976368] May, Bruce, 2025-12-11
eventOf	[Pathway:R-HSA-9976102] Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9976402] GATA3, CHD4, EP300, NFATC2, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL13 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9978103] Gata3, Chd4, Ep300, and Nfatc2 bind the Il13 gene - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-3702078] CHD4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-996768] GATA3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9976405] IL13 gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-2025894] p-S243-NFATC2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9976136] Coordinated regulation of IL-4 and IL-13 expression in human T cells: 3C analysis for DNA looping [LiteratureReference:9977431] GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells [LiteratureReference:9945893] T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements
maxDepth	1
modified	[InstanceEdit:9983731] May, Bruce, 2026-02-26
name	GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene
output	[Complex:R-HSA-9976378] GATA3:CHD4:EP300:p-S243-NFATC2:IL13 gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9976143] STAT6, NFATC2 (NFAT1), and NICD1,2 positively regulate expression of GATA3 - Homo sapiens [BlackBoxEvent:R-HSA-2025882] Calcineurin dephosphorylates NFATC1,2,3 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9983436] Barbutti, Isabella, 2026-02-24 [InstanceEdit:9983730] Lord, Graham M, 2026-02-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9976381
summation	[Summation:9976380] GATA3 and NFATC2 (NFAT1) bind upstream of the IL13 transcrip...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9976402] GATA3, CHD4, EP300, NFATC2, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL13
(hasEvent)	[Pathway:R-HSA-9976102] Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells)
(inferredTo)	[Reaction:R-MMU-9978103] Gata3, Chd4, Ep300, and Nfatc2 bind the Il13 gene