TP53 family members bind the BAX promoter

Stable Identifier
R-HSA-3700981
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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TP53 family members bind the BAX promoter
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TP53 (p53) binds the p53 response element in the promoter of the BAX gene (Miyashita and Reed 1995). TP53 family members TP63 (p63) and TP73 (p73) can also bind the BAX promoter. Complex formation between ASPP proteins PPP1R13B (ASPP1) or TP53BP2 (ASPP2) and p53 family members TP53 (Samuels-Lev et al. 2001), TP63 or TP73 (Bergamaschi et al. 2004) enhances binding of p53 family members to the BAX promoter.

Literature References
PubMed ID Title Journal Year
14729977 ASPP1 and ASPP2: common activators of p53 family members

Bergamaschi, D, Samuels, Y, Jin, B, Duraisingham, S, Crook, T, Lu, X

Mol. Cell. Biol. 2004
11684014 ASPP proteins specifically stimulate the apoptotic function of p53

Samuels-Lev, Y, O'Connor, DJ, Bergamaschi, D, Trigiante, G, Hsieh, JK, Zhong, S, Campargue, I, Naumovski, L, Crook, T, Lu, X

Mol. Cell 2001
7834749 Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

Miyashita, T, Reed, JC

Cell 1995
Participants
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Output
Participant Of
hasEvent
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2013-06-11)