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Schema
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Entries
Metabolism of polyamines
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authored
[InstanceEdit:351169] Gopinathrao, G, 2008-05-21 17:26:32
compartment
[Compartment:70101] cytosol
[Compartment:17951] peroxisomal matrix
created
[InstanceEdit:351224] Gopinathrao, G, 2008-05-21 20:55:45
dbId
351202
displayName
Metabolism of polyamines
doi
10.3180/REACT_14820.1
edited
[InstanceEdit:8982686] D'Eustachio, Peter, 2017-03-21
eventOf
[Pathway:R-HSA-71291] Metabolism of amino acids and derivatives - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:9863] polyamine metabolic process
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-351143] Agmatine biosynthesis - Homo sapiens
[Reaction:R-HSA-9955574] ODC dimerizes - Homo sapiens
[Reaction:R-HSA-70692] ornithine => putrescine + CO2 - Homo sapiens
[Reaction:R-HSA-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Homo sapiens
[Reaction:R-HSA-351215] Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine - Homo sapiens
[Reaction:R-HSA-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - Homo sapiens
[Pathway:R-HSA-351200] Interconversion of polyamines - Homo sapiens
[Pathway:R-HSA-350562] Regulation of ornithine decarboxylase (ODC) - Homo sapiens
[Reaction:R-HSA-9971446] Unknown ALDH oxidizes 3-AAPNAL - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2019-06-12
literatureReference
[LiteratureReference:351220] Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide
[LiteratureReference:351205] Polyamines: metabolism and implications in human diseases
[LiteratureReference:351230] Polyamine metabolism revisited
maxDepth
3
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
Metabolism of polyamines
orthologousEvent
[Pathway:R-MMU-351202] Metabolism of polyamines - Mus musculus
[Pathway:R-RNO-351202] Metabolism of polyamines - Rattus norvegicus
[Pathway:R-CFA-351202] Metabolism of polyamines - Canis familiaris
[Pathway:R-SSC-351202] Metabolism of polyamines - Sus scrofa
[Pathway:R-DRE-351202] Metabolism of polyamines - Danio rerio
[Pathway:R-XTR-351202] Metabolism of polyamines - Xenopus tropicalis
[Pathway:R-GGA-351202] Metabolism of polyamines - Gallus gallus
[Pathway:R-DME-351202] Metabolism of polyamines - Drosophila melanogaster
[Pathway:R-CEL-351202] Metabolism of polyamines - Caenorhabditis elegans
[Pathway:R-DDI-351202] Metabolism of polyamines - Dictyostelium discoideum
[Pathway:R-SPO-351202] Metabolism of polyamines - Schizosaccharomyces pombe
[Pathway:R-SCE-351202] Metabolism of polyamines - Saccharomyces cerevisiae
[Pathway:R-PFA-351202] Metabolism of polyamines - Plasmodium falciparum
[Pathway:R-BTA-351202] Metabolism of polyamines - Bos taurus
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2008-09-30
releaseStatus
UPDATED
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:377465] D'Eustachio, P, 2008-06-12 14:43:38
[InstanceEdit:9963240] D'Eustachio, Peter, 2025-08-13
[InstanceEdit:9971588] D'Eustachio, Peter, 2025-11-07
[InstanceEdit:9971782] D'Eustachio, Peter, 2025-11-11
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-351202
summation
[Summation:353126] Three polyamines - putrescine, spermine, and spermidine - ar...
updateTrackers
[UpdateTracker:9964644] Update Tracker - [Pathway:351202] Metabolism of polyamines - v94:[modifyText, removeHasEvent]
[UpdateTracker:9791166] Update Tracker - [Pathway:351202] Metabolism of polyamines - v32:[removeHasEvent]
[UpdateTracker:9777675] Update Tracker - [Pathway:351202] Metabolism of polyamines - v69:[removeHasEvent]
[UpdateTracker:9783522] Update Tracker - [Pathway:351202] Metabolism of polyamines - v56:[updateIndirectRLE]
[UpdateTracker:9790506] Update Tracker - [Pathway:351202] Metabolism of polyamines - v33:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9786150] Update Tracker - [Pathway:351202] Metabolism of polyamines - v50:[updateIndirectRLE]
[UpdateTracker:9782642] Update Tracker - [Pathway:351202] Metabolism of polyamines - v59:[updateIndirectRLE]
[UpdateTracker:9788983] Update Tracker - [Pathway:351202] Metabolism of polyamines - v39:[updateIndirectRLE]
[UpdateTracker:9784415] Update Tracker - [Pathway:351202] Metabolism of polyamines - v54:[addHasEvent]
[UpdateTracker:9789762] Update Tracker - [Pathway:351202] Metabolism of polyamines - v37:[addHasEvent]
[UpdateTracker:9984701] Update Tracker - [Pathway:351202] Metabolism of polyamines - v96:[removeHasEvent]
[UpdateTracker:9781339] Update Tracker - [Pathway:351202] Metabolism of polyamines - v61:[updateIndirectRLE]
[UpdateTracker:9788567] Update Tracker - [Pathway:351202] Metabolism of polyamines - v41:[updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-71291] Metabolism of amino acids and derivatives
(updatedInstance)
[UpdateTracker:9964644] Update Tracker - [Pathway:351202] Metabolism of polyamines - v94:[modifyText, removeHasEvent]
[UpdateTracker:9791166] Update Tracker - [Pathway:351202] Metabolism of polyamines - v32:[removeHasEvent]
[UpdateTracker:9777675] Update Tracker - [Pathway:351202] Metabolism of polyamines - v69:[removeHasEvent]
[UpdateTracker:9783522] Update Tracker - [Pathway:351202] Metabolism of polyamines - v56:[updateIndirectRLE]
[UpdateTracker:9790506] Update Tracker - [Pathway:351202] Metabolism of polyamines - v33:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9786150] Update Tracker - [Pathway:351202] Metabolism of polyamines - v50:[updateIndirectRLE]
[UpdateTracker:9782642] Update Tracker - [Pathway:351202] Metabolism of polyamines - v59:[updateIndirectRLE]
[UpdateTracker:9788983] Update Tracker - [Pathway:351202] Metabolism of polyamines - v39:[updateIndirectRLE]
[UpdateTracker:9784415] Update Tracker - [Pathway:351202] Metabolism of polyamines - v54:[addHasEvent]
[UpdateTracker:9789762] Update Tracker - [Pathway:351202] Metabolism of polyamines - v37:[addHasEvent]
[UpdateTracker:9984701] Update Tracker - [Pathway:351202] Metabolism of polyamines - v96:[removeHasEvent]
[UpdateTracker:9781339] Update Tracker - [Pathway:351202] Metabolism of polyamines - v61:[updateIndirectRLE]
[UpdateTracker:9788567] Update Tracker - [Pathway:351202] Metabolism of polyamines - v41:[updateIndirectRLE]
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