Metabolism of polyamines

Stable Identifier
Homo sapiens
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Polyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that arginine can be metabolised according to the same pathway leading to agmatine formation. Polyamines are essential for the growth, the maintenance and the function of normal cells. The complexity of their metabolism and the fact that polyamines homeostasis is tightly regulated support the idea that polyamines are essential to cell survival. Multiple abnormalities in the control of polyamines metabolism might be implicated in several pathological processes (Moinard et al., 2005). Legend for the following figure:

Literature References
PubMed ID Title Journal Year
12686127 Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide

Hillary, RA, Pegg, AE

Biochim Biophys Acta 2003
11564948 Polyamine metabolism revisited

Urdiales, JL, Medina, MA, Sánchez-Jiménez, F

Eur J Gastroenterol Hepatol 2001
15784477 Polyamines: metabolism and implications in human diseases

Moinard, C, Cynober, L, de Bandt, JP

Clin Nutr 2005
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