Reactome | ornithine => putrescine + CO2

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ornithine => putrescine + CO2 Show undefined attributes

authored	[InstanceEdit:351144] Gopinathrao, G, 2008-05-21 15:52:50
catalystActivity	[CatalystActivity:70691] ornithine decarboxylase activity of PXLP-K69-ODC1 dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9955561] ornithine decarboxylase activity of PXLP-K69-ODC1 dimer [cytosol] Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667652] RHEA:22965 [DatabaseIdentifier:9955583] RHEA:22965
dbId	70692
displayName	ornithine => putrescine + CO2
edited	[InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
eventOf	[Pathway:R-HSA-351202] Metabolism of polyamines - Homo sapiens
followingEvent	[Reaction:R-HSA-351215] Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29498] L-Orn [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9955578] Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding [LiteratureReference:9955559] A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ornithine => putrescine + CO2 L-ornithine + H(+) => putrescine + CO2
orthologousEvent	[Reaction:R-PFA-70692] ornithine => putrescine + CO2 - Plasmodium falciparum [Reaction:R-SCE-70692] ornithine => putrescine + CO2 - Saccharomyces cerevisiae [Reaction:R-SPO-70692] ornithine => putrescine + CO2 - Schizosaccharomyces pombe [Reaction:R-DDI-70692] ornithine => putrescine + CO2 - Dictyostelium discoideum [Reaction:R-CEL-70692] ornithine => putrescine + CO2 - Caenorhabditis elegans [Reaction:R-DME-70692] ornithine => putrescine + CO2 - Drosophila melanogaster [Reaction:R-GGA-70692] ornithine => putrescine + CO2 - Gallus gallus [Reaction:R-XTR-70692] ornithine => putrescine + CO2 - Xenopus tropicalis [Reaction:R-DRE-70692] ornithine => putrescine + CO2 - Danio rerio [Reaction:R-SSC-70692] ornithine => putrescine + CO2 - Sus scrofa [Reaction:R-BTA-70692] ornithine => putrescine + CO2 - Bos taurus [Reaction:R-CFA-70692] ornithine => putrescine + CO2 - Canis familiaris [Reaction:R-RNO-70692] ornithine => putrescine + CO2 - Rattus norvegicus [Reaction:R-MMU-70692] ornithine => putrescine + CO2 - Mus musculus
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-29610] Putrescine [cytosol]
precedingEvent	[Reaction:R-HSA-9955574] ODC dimerizes - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2008-09-30
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:377465] D'Eustachio, P, 2008-06-12 14:43:38 [InstanceEdit:9974434] D'Eustachio, Peter, 2025-11-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70692
summation	[Summation:179017] L-ornithine is converted into putrescine by cytosolic ornith...
updateTrackers	[UpdateTracker:9791858] Update Tracker - [Reaction:70692] ornithine => putrescine + CO2 - v25:[modifyText] [UpdateTracker:9964627] Update Tracker - [Reaction:70692] ornithine => putrescine + CO2 - v94:[add_removeLiteratureReference, modifyText, removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9791858] Update Tracker - [Reaction:70692] ornithine => putrescine + CO2 - v25:[modifyText] [UpdateTracker:9964627] Update Tracker - [Reaction:70692] ornithine => putrescine + CO2 - v94:[add_removeLiteratureReference, modifyText, removeInput]
(hasEvent)	[Pathway:R-HSA-351202] Metabolism of polyamines
(precedingEvent)	[Reaction:R-HSA-351215] Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine

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