Reactome | dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine

Schema > Reaction > Entries

dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine Show undefined attributes

authored	[InstanceEdit:351144] Gopinathrao, G, 2008-05-21 15:52:50
catalystActivity	[CatalystActivity:351216] spermine synthase activity of SMS [cytosol]
catalystActivityReference	[CatalystActivityReference:9955577] spermine synthase activity of SMS [cytosol] Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667655] RHEA:19974 [DatabaseIdentifier:9955571] RHEA:19974
dbId	351210
displayName	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine
edited	[InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
eventOf	[Pathway:R-HSA-351202] Metabolism of polyamines - Homo sapiens
followingEvent	[Reaction:R-HSA-351207] Spermine => N-acetylated spermine - Homo sapiens [Reaction:R-HSA-1237160] MTA is cleaved and phosphorylated - Homo sapiens
input	[SimpleEntity:R-ALL-353113] dc-AdoMet [cytosol] [SimpleEntity:R-ALL-204635] SPM [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:353537] Molecular cloning of a cDNA encoding human spermine synthase [LiteratureReference:9955557] Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => spermine + S-methyl-5'-thioadenosine + H(+)
orthologousEvent	[Reaction:R-DME-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - Drosophila melanogaster [Reaction:R-GGA-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - Gallus gallus [Reaction:R-XTR-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - Xenopus tropicalis [Reaction:R-DRE-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - Danio rerio [Reaction:R-SSC-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - Sus scrofa [Reaction:R-BTA-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - Bos taurus [Reaction:R-CFA-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - Canis familiaris [Reaction:R-RNO-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - Rattus norvegicus [Reaction:R-MMU-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - Mus musculus
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-353106] MTAD [cytosol] [SimpleEntity:R-ALL-353560] SPN [cytosol]
precedingEvent	[Reaction:R-HSA-351215] Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine - Homo sapiens [Reaction:R-HSA-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2008-09-30
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:377465] D'Eustachio, P, 2008-06-12 14:43:38 [InstanceEdit:9974434] D'Eustachio, Peter, 2025-11-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-351210
summation	[Summation:353539] Spermine synthase (SMS), a member of the spermidine/spermine...
updateTrackers	[UpdateTracker:9964692] Update Tracker - [Reaction:351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - v94:[modifyText, removeLiteratureReference, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9964692] Update Tracker - [Reaction:351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - v94:[modifyText, removeLiteratureReference, removeOutput]
(hasEvent)	[Pathway:R-HSA-351202] Metabolism of polyamines
(precedingEvent)	[Reaction:R-HSA-351207] Spermine => N-acetylated spermine [Reaction:R-HSA-1237160] MTA is cleaved and phosphorylated