miR-24 binds p16INK4A and p14ARF mRNAs

Stable Identifier
R-HSA-3209151
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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MicroRNA miR-24 is able to bind both p16INK4A mRNA (Lal et al. 2008) and p14ARF mRNA (To et al. 2012) through their shared 3'UTR. miR-24 inhibits translation of p16INK4A and p14ARF mRNAs, but does not induce mRNA degradation, resulting in expression of high levels of p16INK4A and p14ARF transcripts, while protein levels of p16INK4A and p14ARF are low (Lal et al. 2008, To et al. 2012).

Literature References
PubMed ID Title Journal Year
22336108 Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development

To, KH, Pajovic, S, Gallie, BL, Thériault, BL

BMC Cancer 2012
18365017 p16(INK4a) translation suppressed by miR-24

Lal, A, Kim, HH, Abdelmohsen, K, Kuwano, Y, Pullmann, R, Srikantan, S, Subrahmanyam, R, Martindale, JL, Yang, X, Ahmed, F, Navarro, F, Dykxhoorn, D, Lieberman, J, Gorospe, M

PLoS ONE 2008
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