miR-24 binds p16INK4A and p14ARF mRNAs

Stable Identifier
R-HSA-3209151
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MicroRNA miR-24 is able to bind both p16INK4A mRNA (Lal et al. 2008) and p14ARF mRNA (To et al. 2012) through their shared 3'UTR. miR-24 inhibits translation of p16INK4A and p14ARF mRNAs, but does not induce mRNA degradation, resulting in expression of high levels of p16INK4A and p14ARF transcripts, while protein levels of p16INK4A and p14ARF are low (Lal et al. 2008, To et al. 2012).
Literature References
PubMed ID Title Journal Year
18365017 p16(INK4a) translation suppressed by miR-24

Yang, X, Pullmann, R, Gorospe, M, Dykxhoorn, D, Lal, A, Martindale, JL, Abdelmohsen, K, Srikantan, S, Subrahmanyam, R, Lieberman, J, Kim, HH, Kuwano, Y, Ahmed, F, Navarro, F

PLoS ONE 2008
22336108 Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development

Thériault, BL, Gallie, BL, To, KH, Pajovic, S

BMC Cancer 2012
Participants
Participates
Authored
Reviewed
Created
Cite Us!