Reactome | p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA

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p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:3209104] Orlic-Milacic, M, 2013-03-01
dbId	3209098
displayName	p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559585] Oncogene Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-3209151] miR-24 binds p16INK4A and p14ARF mRNAs - Homo sapiens [BlackBoxEvent:R-HSA-3209114] Translation of p16INK4A mRNA is inhibited by miR-24 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3200017] CDKN2A gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3200021] Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA
output	[EntityWithAccessionedSequence:R-HSA-3209105] p16INK4A mRNA [cytosol]
precedingEvent	[Reaction:R-HSA-3200023] Phosphorylated ETS1 binds p16INK4A promoter - Homo sapiens [Reaction:R-HSA-8979082] Phosphorylated ETS2 binds p16INK4A promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-3209116] Positive gene expression regulation by 'p-T38-ETS1/ p-T72-ETS2:CDKN2A Gene [nucleoplasm]'
regulationReference	[RegulationReference:9641721] Positive gene expression regulation by 'p-T38-ETS1/ p-T72-ETS2:CDKN2A Gene [nucleoplasm]' Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-3209098
summation	[Summation:3245935] Phosphorylated ETS1 and ETS2 stimulate p16INK4A transcriptio...
updateTrackers	[UpdateTracker:9777758] Update Tracker - [BlackBoxEvent:3209098] p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA - v69:[modifyText]

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(updatedInstance)	[UpdateTracker:9777758] Update Tracker - [BlackBoxEvent:3209098] p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA - v69:[modifyText]
(hasEvent)	[Pathway:R-HSA-2559585] Oncogene Induced Senescence
(precedingEvent)	[Reaction:R-HSA-3209151] miR-24 binds p16INK4A and p14ARF mRNAs [BlackBoxEvent:R-HSA-3209114] Translation of p16INK4A mRNA is inhibited by miR-24

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