Reactome | E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA

Schema > BlackBoxEvent > Entries

E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:3209104] Orlic-Milacic, M, 2013-03-01
dbId	3209109
displayName	E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559585] Oncogene Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-3209151] miR-24 binds p16INK4A and p14ARF mRNAs - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3200017] CDKN2A gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3209099] Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors [LiteratureReference:8979099] Distinct E2F-mediated transcriptional program regulates p14ARF gene expression
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA
output	[EntityWithAccessionedSequence:R-HSA-3209107] p14ARF mRNA [cytosol]
precedingEvent	[Reaction:R-HSA-3209096] E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-3209108] Positive gene expression regulation by 'DP1/2: E2F1/2/3: SP1: CDKN2A Gene [nucleoplasm]' [NegativeRegulation:R-HSA-8979098] Negative regulation by 'RB1 [nucleoplasm]'
regulationReference	[RegulationReference:9641522] Positive gene expression regulation by 'DP1/2: E2F1/2/3: SP1: CDKN2A Gene [nucleoplasm]' Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors [RegulationReference:9642321] Negative regulation by 'RB1 [nucleoplasm]' Distinct E2F-mediated transcriptional program regulates p14ARF gene expression
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-3209109
summation	[Summation:3245957] E2F1, E2F2 or E2F3 in complex with SP1 stimulates p14ARF tra...
updateTrackers	[UpdateTracker:9777746] Update Tracker - [BlackBoxEvent:3209109] E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA - v69:[modifyText] [UpdateTracker:9781620] Update Tracker - [BlackBoxEvent:3209109] E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA - v60:[addLiteratureReference, addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777746] Update Tracker - [BlackBoxEvent:3209109] E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA - v69:[modifyText] [UpdateTracker:9781620] Update Tracker - [BlackBoxEvent:3209109] E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA - v60:[addLiteratureReference, addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-2559585] Oncogene Induced Senescence
(precedingEvent)	[Reaction:R-HSA-3209151] miR-24 binds p16INK4A and p14ARF mRNAs