Reactome | NOTCH2 Activation and Transmission of Signal to the Nucleus

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NOTCH2 Activation and Transmission of Signal to the Nucleus Show undefined attributes

authored	[InstanceEdit:2980678] Orlic-Milacic, M, 2013-01-11
created	[InstanceEdit:2979098] Orlic-Milacic, M, 2013-01-10
dbId	2979096
displayName	NOTCH2 Activation and Transmission of Signal to the Nucleus
doi	10.3180/R-HSA-2979096.5
edited	[InstanceEdit:3159303] Haw, R, 2013-01-14 [InstanceEdit:9925757] Orlic-Milacic, Marija, 2024-10-23
eventOf	[Pathway:R-HSA-1980145] Signaling by NOTCH2 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1980048] DLL1 binds NOTCH2 - Homo sapiens [Reaction:R-HSA-1980056] JAG1 binds NOTCH2 - Homo sapiens [Reaction:R-HSA-1980061] JAG2 binds NOTCH2 - Homo sapiens [Reaction:R-HSA-1980051] DLL4 binds NOTCH2 - Homo sapiens [Reaction:R-HSA-2172172] Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 - Homo sapiens [Reaction:R-HSA-157629] NOTCH2-ligand complex is cleaved to produce NEXT2 - Homo sapiens [Reaction:R-HSA-157640] NEXT2 is cleaved to produce NICD2 - Homo sapiens [Reaction:R-HSA-157933] NICD2 traffics to the nucleus - Homo sapiens [Reaction:R-HSA-2220816] NOTCH2 binds CNTN1 - Homo sapiens [BlackBoxEvent:R-HSA-2974731] Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 - Homo sapiens [Reaction:R-HSA-2974737] NOTCH2 binds MDK - Homo sapiens [Reaction:R-HSA-9911648] NOTCH2 binds DLL/JAG ligand in cis - Homo sapiens [BlackBoxEvent:R-HSA-9911661] NOTCH2NLB, (NOTCH2NLA, NOTCH2NLC) bind DLL1, (DLL4, JAG1, JAG2) - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-09-27
literatureReference	[LiteratureReference:157133] Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2 [LiteratureReference:2168111] Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2 [LiteratureReference:2169058] Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods [LiteratureReference:2168113] Function of Delta4 gene and its effects on 32D cell differentiation [LiteratureReference:2172161] ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo [LiteratureReference:2197549] Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis [LiteratureReference:163904] A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain [LiteratureReference:2974760] Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer [LiteratureReference:373542] F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation [LiteratureReference:2974758] Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	NOTCH2 Activation and Transmission of Signal to the Nucleus
orthologousEvent	[Pathway:R-DME-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Drosophila melanogaster [Pathway:R-CEL-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Caenorhabditis elegans [Pathway:R-GGA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Gallus gallus [Pathway:R-XTR-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Xenopus tropicalis [Pathway:R-DRE-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Danio rerio
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3448657] Boyle, Scott, 2013-04-25 [InstanceEdit:3448655] Ilagan, Ma Xenia, 2013-04-25 [InstanceEdit:9925739] Heide, Michael, 2024-10-25
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2979096
summation	[Summation:2979097] Similar to NOTCH1, NOTCH2 is activated by Delta-like and Jag...
updateTrackers	[UpdateTracker:9928476] Update Tracker - [Pathway:2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - v91:[removeHasEvent] [UpdateTracker:9780574] Update Tracker - [Pathway:2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - v62:[updateContainedRLE] [UpdateTracker:9787461] Update Tracker - [Pathway:2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - v45:[addHasEvent, addLiteratureReference, modifyText, updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9928476] Update Tracker - [Pathway:2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - v91:[removeHasEvent]
[UpdateTracker:9780574] Update Tracker - [Pathway:2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - v62:[updateContainedRLE]
[UpdateTracker:9787461] Update Tracker - [Pathway:2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - v45:[addHasEvent, addLiteratureReference, modifyText, updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-1980145] Signaling by NOTCH2

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