Reactome | Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2

Schema > BlackBoxEvent > Entries

Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 Show undefined attributes

authored	[InstanceEdit:2980678] Orlic-Milacic, M, 2013-01-11
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2974729] Orlic-Milacic, M, 2013-01-07
dbId	2974731
displayName	Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
edited	[InstanceEdit:3159303] Haw, R, 2013-01-14
entityOnOtherCell	[EntityWithAccessionedSequence:R-HSA-373622] CNTN1 [plasma membrane] - Homo sapiens
eventOf	[Pathway:R-HSA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Homo sapiens
inferredFrom	[BlackBoxEvent:R-NUL-2974720] Gamma-secretase cleaves Cntn1:Notch2 to release NICD2 - Mus musculus
input	[Complex:R-HSA-2220817] CNTN1:NOTCH2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:373542] F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
output	[EntityWithAccessionedSequence:R-HSA-157642] NICD2 [cytosol]
precedingEvent	[Reaction:R-HSA-2220816] NOTCH2 binds CNTN1 - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-2974728] Positive regulation by 'gamma-secretase complex [plasma membrane]'
regulationReference	[RegulationReference:9642942] Positive regulation by 'gamma-secretase complex [plasma membrane]' F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3448657] Boyle, Scott, 2013-04-25 [InstanceEdit:3448655] Ilagan, Ma Xenia, 2013-04-25
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2974731
summation	[Summation:2974730] Binding of CNTN1 to NOTCH2 results in release of the intrace...

Referrals

(hasEvent)	[Pathway:R-HSA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus
(inferredTo)	[BlackBoxEvent:R-NUL-2974720] Gamma-secretase cleaves Cntn1:Notch2 to release NICD2

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