Reactome | Ubiquitination of DLL/JAG ligands upon binding to NOTCH2

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Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 Show undefined attributes

authored	[InstanceEdit:2980678] Orlic-Milacic, M, 2013-01-11
catalystActivity	[CatalystActivity:1980072] ubiquitin-protein transferase activity of MIB/NEURL [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2172167] Orlic-Milacic, M, 2012-03-28
dbId	2172172
displayName	Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06 [InstanceEdit:3159303] Haw, R, 2013-01-14
entityOnOtherCell	[CandidateSet:R-HSA-1911464] MIB/NEURL [cytosol] - Homo sapiens [DefinedSet:R-HSA-157643] DLL/JAG [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-113595] Ub [cytosol] - Homo sapiens
eventOf	[Pathway:R-HSA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Homo sapiens
followingEvent	[Reaction:R-HSA-157629] NOTCH2-ligand complex is cleaved to produce NEXT2 - Homo sapiens
inferredFrom	[Reaction:R-DME-209226] DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1) - Drosophila melanogaster
input	[DefinedSet:R-HSA-157637] DLL/JAG:NOTCH2 [plasma membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2172175] Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain [LiteratureReference:1602210] An obligatory role of mind bomb-1 in notch signaling of mammalian development [LiteratureReference:1602191] Mind bomb-2 is an E3 ligase for Notch ligand [LiteratureReference:1602202] Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta [LiteratureReference:208262] The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta [LiteratureReference:208089] Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila [LiteratureReference:208396] The interplay between DSL proteins and ubiquitin ligases in Notch signaling [LiteratureReference:208133] Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta [LiteratureReference:2084254] Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1 [LiteratureReference:2084252] Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1 [LiteratureReference:3446293] Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis [LiteratureReference:3446298] Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
output	[Complex:R-HSA-2172171] Ub-DLL/JAG:NOTCH2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1980048] DLL1 binds NOTCH2 - Homo sapiens [Reaction:R-HSA-1980051] DLL4 binds NOTCH2 - Homo sapiens [Reaction:R-HSA-1980056] JAG1 binds NOTCH2 - Homo sapiens [Reaction:R-HSA-1980061] JAG2 binds NOTCH2 - Homo sapiens
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3159303] Haw, R, 2013-01-14 [InstanceEdit:3448657] Boyle, Scott, 2013-04-25 [InstanceEdit:3448655] Ilagan, Ma Xenia, 2013-04-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2172172
summation	[Summation:2172163] NOTCH ligands DLL1, DLL4, JAG1 and JAG2 undergo ubiquitinati...
updateTrackers	[UpdateTracker:9787512] Update Tracker - [Reaction:2172172] Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 - v45:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787512] Update Tracker - [Reaction:2172172] Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 - v45:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus
(precedingEvent)	[Reaction:R-HSA-157629] NOTCH2-ligand complex is cleaved to produce NEXT2
(inferredTo)	[Reaction:R-DME-209226] DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1)

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