Reactome | NOTCH2-ligand complex is cleaved to produce NEXT2

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NOTCH2-ligand complex is cleaved to produce NEXT2 Show undefined attributes

authored	[InstanceEdit:2980678] Orlic-Milacic, M, 2013-01-11
catalystActivity	[CatalystActivity:157208] metallopeptidase activity of ADAM10:Zn2+ [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:157631] Jassal, B, 2005-01-04 16:01:41
dbId	157629
displayName	NOTCH2-ligand complex is cleaved to produce NEXT2
edited	[InstanceEdit:3159303] Haw, R, 2013-01-14
entityOnOtherCell	[DefinedSet:R-HSA-157643] DLL/JAG [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-113595] Ub [cytosol] - Homo sapiens
eventOf	[Pathway:R-HSA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Homo sapiens
followingEvent	[Reaction:R-HSA-157640] NEXT2 is cleaved to produce NICD2 - Homo sapiens
inferredFrom	[Reaction:R-MMU-2193065] Adam10 cleaves Notch2 - Mus musculus
input	[Complex:R-HSA-2172171] Ub-DLL/JAG:NOTCH2 [plasma membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2172161] ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo [LiteratureReference:157133] Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2 [LiteratureReference:3446298] Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin [LiteratureReference:9013285] Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH2-ligand complex is cleaved to produce NEXT2
output	[EntityWithAccessionedSequence:R-HSA-157225] NEXT2 [plasma membrane] [Complex:R-HSA-157630] NOTCH2 fragment:DLL/JAG [plasma membrane]
precedingEvent	[Reaction:R-HSA-2172172] Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3448657] Boyle, Scott, 2013-04-25 [InstanceEdit:3448655] Ilagan, Ma Xenia, 2013-04-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-157629
summation	[Summation:178988] Ligand binding induces a conformational change in NOTCH2, th...
updateTrackers	[UpdateTracker:9780567] Update Tracker - [Reaction:157629] NOTCH2-ligand complex is cleaved to produce NEXT2 - v62:[addLiteratureReference, modifyText] [UpdateTracker:9787737] Update Tracker - [Reaction:157629] NOTCH2-ligand complex is cleaved to produce NEXT2 - v44:[add_removeInput, modifyText] [UpdateTracker:9789397] Update Tracker - [Reaction:157629] NOTCH2-ligand complex is cleaved to produce NEXT2 - v38:[modifyText] [UpdateTracker:9788613] Update Tracker - [Reaction:157629] NOTCH2-ligand complex is cleaved to produce NEXT2 - v41:[add_removeInput, add_removeLiteratureReference, modifyText] [UpdateTracker:9787324] Update Tracker - [Reaction:157629] NOTCH2-ligand complex is cleaved to produce NEXT2 - v45:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9780567] Update Tracker - [Reaction:157629] NOTCH2-ligand complex is cleaved to produce NEXT2 - v62:[addLiteratureReference, modifyText] [UpdateTracker:9787737] Update Tracker - [Reaction:157629] NOTCH2-ligand complex is cleaved to produce NEXT2 - v44:[add_removeInput, modifyText] [UpdateTracker:9789397] Update Tracker - [Reaction:157629] NOTCH2-ligand complex is cleaved to produce NEXT2 - v38:[modifyText] [UpdateTracker:9788613] Update Tracker - [Reaction:157629] NOTCH2-ligand complex is cleaved to produce NEXT2 - v41:[add_removeInput, add_removeLiteratureReference, modifyText] [UpdateTracker:9787324] Update Tracker - [Reaction:157629] NOTCH2-ligand complex is cleaved to produce NEXT2 - v45:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus
(precedingEvent)	[Reaction:R-HSA-157640] NEXT2 is cleaved to produce NICD2
(inferredTo)	[Reaction:R-MMU-2193065] Adam10 cleaves Notch2

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