Reactome | Signaling by NOTCH2

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Signaling by NOTCH2 Show undefined attributes

authored	[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:1980146] Orlic-Milacic, M, 2011-11-08
dbId	1980145
displayName	Signaling by NOTCH2
doi	10.3180/REACT_118721.4
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10
eventOf	[Pathway:R-HSA-157118] Signaling by NOTCH - Homo sapiens
figure	[Figure:2291902] /figures/Pathway_Illustrations/NOTCH2_72_oicr.png
goBiologicalProcess	[GO_BiologicalProcess:20089] Notch signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Homo sapiens [Pathway:R-HSA-2197563] NOTCH2 intracellular domain regulates transcription - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-09-30
literatureReference	[LiteratureReference:157133] Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2 [LiteratureReference:2168111] Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2 [LiteratureReference:2169058] Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods [LiteratureReference:2168113] Function of Delta4 gene and its effects on 32D cell differentiation [LiteratureReference:2172161] ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo [LiteratureReference:2197549] Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis [LiteratureReference:163904] A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain [LiteratureReference:2025785] Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells [LiteratureReference:2974760] Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer [LiteratureReference:373542] F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation [LiteratureReference:2974758] Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes [LiteratureReference:2127284] Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia [LiteratureReference:2976559] Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity [LiteratureReference:2025784] NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway [LiteratureReference:2197547] Functional diversity among Notch1, Notch2, and Notch3 receptors [LiteratureReference:2197584] MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors [LiteratureReference:1497893] The canonical Notch signaling pathway: unfolding the activation mechanism [LiteratureReference:2153481] Canonical and non-canonical Notch ligands [LiteratureReference:3321790] Mechanistic insights into Notch receptor signaling from structural and biochemical studies [LiteratureReference:3322874] Hepatic ductular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental, and sexual development, and cardiac murmur [LiteratureReference:3322873] Mutations in the human Jagged1 gene are responsible for Alagille syndrome [LiteratureReference:3322887] Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1 [LiteratureReference:3322899] Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss [LiteratureReference:3322922] Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis [LiteratureReference:3322890] Mutations in NOTCH2 in families with Hajdu-Cheney syndrome
maxDepth	3
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Signaling by NOTCH2
orthologousEvent	[Pathway:R-DRE-1980145] Signaling by NOTCH2 - Danio rerio [Pathway:R-XTR-1980145] Signaling by NOTCH2 - Xenopus tropicalis [Pathway:R-GGA-1980145] Signaling by NOTCH2 - Gallus gallus [Pathway:R-CEL-1980145] Signaling by NOTCH2 - Caenorhabditis elegans [Pathway:R-DME-1980145] Signaling by NOTCH2 - Drosophila melanogaster
releaseDate	2005-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165114] Joutel, A, 2004-12-15 [InstanceEdit:3448657] Boyle, Scott, 2013-04-25 [InstanceEdit:3448655] Ilagan, Ma Xenia, 2013-04-25
revised	[InstanceEdit:2980678] Orlic-Milacic, M, 2013-01-11
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1980145
summation	[Summation:2122955] NOTCH2 is activated by binding Delta-like and Jagged ligands...
updateTrackers	[UpdateTracker:9788053] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v44:[addLiteratureReference, add_removeHasEvent, modifyText] [UpdateTracker:9780758] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v62:[updateIndirectRLE] [UpdateTracker:9779050] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v66:[updateIndirectRLE] [UpdateTracker:9788699] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v41:[updateContainedRLE] [UpdateTracker:9787399] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v45:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-157118] Signaling by NOTCH
(hasEncapsulatedEvent)	[Pathway:R-HSA-1912422] Pre-NOTCH Expression and Processing
(updatedInstance)	[UpdateTracker:9788053] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v44:[addLiteratureReference, add_removeHasEvent, modifyText] [UpdateTracker:9780758] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v62:[updateIndirectRLE] [UpdateTracker:9779050] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v66:[updateIndirectRLE] [UpdateTracker:9788699] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v41:[updateContainedRLE] [UpdateTracker:9787399] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v45:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateIndirectRLE]

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