Reactome | NEXT2 is cleaved to produce NICD2

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NEXT2 is cleaved to produce NICD2 Show undefined attributes

authored	[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
catalystActivity	[CatalystActivity:157355] aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:157354] Jassal, B, 2004-12-21 14:32:26
dbId	157640
displayName	NEXT2 is cleaved to produce NICD2
edited	[InstanceEdit:3159303] Haw, R, 2013-01-14
eventOf	[Pathway:R-HSA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Homo sapiens
followingEvent	[Reaction:R-HSA-157933] NICD2 traffics to the nucleus - Homo sapiens
inferredFrom	[Reaction:R-NUL-2197556] Gamma-secretase complex cleaves mNEXT2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-157225] NEXT2 [plasma membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2197549] Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis [LiteratureReference:163904] A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain [LiteratureReference:163911] Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain [LiteratureReference:157796] Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling [LiteratureReference:9013285] Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NEXT2 is cleaved to produce NICD2
output	[EntityWithAccessionedSequence:R-HSA-157642] NICD2 [cytosol] [EntityWithAccessionedSequence:R-HSA-157628] NOTCH2(1666-1696) [plasma membrane]
precedingEvent	[Reaction:R-HSA-157629] NOTCH2-ligand complex is cleaved to produce NEXT2 - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3448657] Boyle, Scott, 2013-04-25 [InstanceEdit:3448655] Ilagan, Ma Xenia, 2013-04-25
revised	[InstanceEdit:2980678] Orlic-Milacic, M, 2013-01-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-157640
summation	[Summation:178971] NEXT2 fragment of NOTCH2 is further cleaved at the S3 site b...
updateTrackers	[UpdateTracker:9787829] Update Tracker - [Reaction:157640] NEXT2 is cleaved to produce NICD2 - v44:[modifyText] [UpdateTracker:9789153] Update Tracker - [Reaction:157640] NEXT2 is cleaved to produce NICD2 - v38:[modifyText] [UpdateTracker:9780648] Update Tracker - [Reaction:157640] NEXT2 is cleaved to produce NICD2 - v62:[addLiteratureReference] [UpdateTracker:9788568] Update Tracker - [Reaction:157640] NEXT2 is cleaved to produce NICD2 - v41:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9787829] Update Tracker - [Reaction:157640] NEXT2 is cleaved to produce NICD2 - v44:[modifyText] [UpdateTracker:9789153] Update Tracker - [Reaction:157640] NEXT2 is cleaved to produce NICD2 - v38:[modifyText] [UpdateTracker:9780648] Update Tracker - [Reaction:157640] NEXT2 is cleaved to produce NICD2 - v62:[addLiteratureReference] [UpdateTracker:9788568] Update Tracker - [Reaction:157640] NEXT2 is cleaved to produce NICD2 - v41:[addLiteratureReference]
(precedingEvent)	[Reaction:R-HSA-157933] NICD2 traffics to the nucleus
(hasEvent)	[Pathway:R-HSA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus
(inferredTo)	[Reaction:R-NUL-2197556] Gamma-secretase complex cleaves mNEXT2

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