Reactome | Translocation of CaN:CaM:NFAT to nucleus

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Translocation of CaN:CaM:NFAT to nucleus Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:2730834] Garapati, P V, 2012-12-05
dbId	2730867
displayName	Translocation of CaN:CaM:NFAT to nucleus
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-5607763] CLEC7A (Dectin-1) induces NFAT activation - Homo sapiens [Pathway:R-HSA-2871809] FCERI mediated Ca+2 mobilization - Homo sapiens
followingEvent	[Reaction:R-HSA-9942683] p-STAT1 and NFATC1 bind the TBX21 gene - Homo sapiens
input	[Complex:R-HSA-2685705] NFAT:CaN:CaM [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2025907] Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Translocation of CaN:CaM:NFAT to nucleus
orthologousEvent	[Reaction:R-CEL-2730867] Translocation of CaN:CaM:NFAT to nucleus - Caenorhabditis elegans [Reaction:R-DME-2730867] Translocation of CaN:CaM:NFAT to nucleus - Drosophila melanogaster [Reaction:R-GGA-2730867] Translocation of CaN:CaM:NFAT to nucleus - Gallus gallus [Reaction:R-XTR-2730867] Translocation of CaN:CaM:NFAT to nucleus - Xenopus tropicalis [Reaction:R-DRE-2730867] Translocation of CaN:CaM:NFAT to nucleus - Danio rerio [Reaction:R-SSC-2730867] Translocation of CaN:CaM:NFAT to nucleus - Sus scrofa [Reaction:R-BTA-2730867] Translocation of CaN:CaM:NFAT to nucleus - Bos taurus [Reaction:R-CFA-2730867] Translocation of CaN:CaM:NFAT to nucleus - Canis familiaris [Reaction:R-RNO-2730867] Translocation of CaN:CaM:NFAT to nucleus - Rattus norvegicus [Reaction:R-MMU-2730867] Translocation of CaN:CaM:NFAT to nucleus - Mus musculus
output	[Complex:R-HSA-2685690] NFAT:CaN:CaM [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-2730849] Calcineurin binds and dephosphorylates NFAT - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2730867
summation	[Summation:2685539] Dephosphorylated NFAT-calcineurin (CaN) complex translocates...
updateTrackers	[UpdateTracker:9953715] Update Tracker - [Reaction:2730867] Translocation of CaN:CaM:NFAT to nucleus - v93:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9953715] Update Tracker - [Reaction:2730867] Translocation of CaN:CaM:NFAT to nucleus - v93:[modifyText]
(precedingEvent)	[Reaction:R-HSA-9942683] p-STAT1 and NFATC1 bind the TBX21 gene
(hasEvent)	[Pathway:R-HSA-5607763] CLEC7A (Dectin-1) induces NFAT activation [Pathway:R-HSA-2871809] FCERI mediated Ca+2 mobilization