Reactome | Calcineurin binds and dephosphorylates NFAT

Schema > BlackBoxEvent > Entries

Calcineurin binds and dephosphorylates NFAT Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
catalystActivity	[CatalystActivity:2730838] calmodulin-dependent protein phosphatase activity of Calcineurin:Calmodulin (CaN:CaM) [cytosol]
catalystActivityReference	[CatalystActivityReference:9644757] calmodulin-dependent protein phosphatase activity of Calcineurin:Calmodulin (CaN:CaM) [cytosol] Transcriptional regulation by calcium, calcineurin, and NFAT
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2730834] Garapati, P V, 2012-12-05
dbId	2730849
displayName	Calcineurin binds and dephosphorylates NFAT
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-5607763] CLEC7A (Dectin-1) induces NFAT activation - Homo sapiens [Pathway:R-HSA-2871809] FCERI mediated Ca+2 mobilization - Homo sapiens
followingEvent	[Reaction:R-HSA-2730867] Translocation of CaN:CaM:NFAT to nucleus - Homo sapiens
input	[Complex:R-HSA-2025947] Calcineurin:Calmodulin (CaN:CaM) [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-HSA-2025924] p-NFATC1,2,3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2685068] Structure of the calcineurin-NFAT complex: defining a T cell activation switch using solution NMR and crystal coordinates [LiteratureReference:2025907] Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity [LiteratureReference:2685136] Transcriptional regulation by calcium, calcineurin, and NFAT [LiteratureReference:2025995] A second calcineurin binding site on the NFAT regulatory domain [LiteratureReference:2025900] Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import [LiteratureReference:2025891] Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Calcineurin binds and dephosphorylates NFAT
orthologousEvent	[BlackBoxEvent:R-DME-2730849] Calcineurin binds and dephosphorylates NFAT - Drosophila melanogaster [BlackBoxEvent:R-BTA-2730849] Calcineurin binds and dephosphorylates NFAT - Bos taurus [BlackBoxEvent:R-CFA-2730849] Calcineurin binds and dephosphorylates NFAT - Canis familiaris [BlackBoxEvent:R-RNO-2730849] Calcineurin binds and dephosphorylates NFAT - Rattus norvegicus [BlackBoxEvent:R-MMU-2730849] Calcineurin binds and dephosphorylates NFAT - Mus musculus
output	[Complex:R-HSA-2685705] NFAT:CaN:CaM [cytosol] 13 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-2730872] Activation of Calcineurin - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2730849
summation	[Summation:2685572] Nuclear factor of activated T-cells (NFAT) is a transcripti...

Referrals

(hasEvent)	[Pathway:R-HSA-5607763] CLEC7A (Dectin-1) induces NFAT activation [Pathway:R-HSA-2871809] FCERI mediated Ca+2 mobilization
(precedingEvent)	[Reaction:R-HSA-2730867] Translocation of CaN:CaM:NFAT to nucleus