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NICD1 PEST Domain Mutants [nucleoplasm]
Stable Identifier
R-HSA-2769016
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
CDK8 phosphorylates NICD1 PEST domain mutants (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants translocate from cytosol to nucleus (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants bind HES1 promoter (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:HES1 Gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants bind HES5 promoter (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:HES5 Gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants bind MYC promoter (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:MYC Gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants bind promoters of HEY genes (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:HEY Genes [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants stimulate HES1 transcription (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:HES1 Gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants stimulate HES5 transcription (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:HES5 Gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants stimulate HEY transcription (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:HEY Genes [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants stimulate MYC transcription (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:MYC Gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
CDK8 phosphorylates NICD1 PEST domain mutants (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants translocate from cytosol to nucleus (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants bind HES1 promoter (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:HES1 Gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants bind HES5 promoter (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:HES5 Gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants bind MYC promoter (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:MYC Gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants bind promoters of HEY genes (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:HEY Genes [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants stimulate HES1 transcription (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:HES1 Gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants stimulate HES5 transcription (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:HES5 Gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants stimulate HEY transcription (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:HEY Genes [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants stimulate MYC transcription (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:MYC Gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
NICD1 PEST Domain Mutants [nucleoplasm] (Homo sapiens)
Participants
members
NICD1 P2514Rfs*4 [nucleoplasm]
(Homo sapiens)
NICD1 Q2440* [nucleoplasm]
(Homo sapiens)
NICD1 Q2395* [nucleoplasm]
(Homo sapiens)
NICD1 P2474Afs*4 [nucleoplasm]
(Homo sapiens)
Participates
as an output of
NICD1 PEST domain mutants translocate from cytosol to nucleus (Homo sapiens)
as an input of
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)
as a component of
NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia
DOID:5603
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