Reactome | Autophosphorylation of PAK

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Autophosphorylation of PAK Show undefined attributes

catalystActivity	[CatalystActivity:10046245] protein serine/threonine kinase activity of p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10046247
displayName	Autophosphorylation of PAK
eventOf	[Pathway:R-MMU-2871796] FCERI mediated MAPK activation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2730856] Autophosphorylation of PAK - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-2685694] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Autophosphorylation of PAK
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] 2 × [DefinedSet:R-MMU-5567354] p-2Y-PAK [cytosol] [Complex:R-MMU-2685706] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane]
precedingEvent	[Reaction:R-MMU-2730889] Recruitment of PAK to the membrane by binding active RAC1 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2730856
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2871796] FCERI mediated MAPK activation
(inferredTo)	[Reaction:R-HSA-2730856] Autophosphorylation of PAK