Autophosphorylation of PAK

Stable Identifier
R-HSA-2730856
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
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Autophosphorylation of PAK
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Upon dimer disassociation PAK1 autophosphorylates in both cis- and trans- manner. Serine 144 (S144) in the GTPase-binding domain and threonine 423 (T423) in the activation loop are the target sites for autophosphorylation (Parrini et al. 2002).

Literature References
PubMed ID Title Journal Year
11278486 The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

Chong, C, Tan, L, Lim, L, Manser, E

J Biol Chem 2001
11804587 Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

Parrini, MC, Lei, M, Harrison, SC, Mayer, BJ

Mol Cell 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane]
Physical Entity
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
Autophosphorylation of PAK (Bos taurus)
Autophosphorylation of PAK (Canis familiaris)
Autophosphorylation of PAK (Danio rerio)
Autophosphorylation of PAK (Drosophila melanogaster)
Autophosphorylation of PAK (Gallus gallus)
Autophosphorylation of PAK (Mus musculus)
Autophosphorylation of PAK (Rattus norvegicus)
Autophosphorylation of PAK (Sus scrofa)
Autophosphorylation of PAK (Xenopus tropicalis)
Authored
Niarakis, A  (2012-12-21)
Reviewed
Roncagalli, R  (2013-02-13)
Created
Garapati, P V  (2012-12-05)