Upon dimer disassociation PAK1 autophosphorylates in both cis- and trans- manner. Serine 144 (S144) in the GTPase-binding domain and threonine 423 (T423) in the activation loop are the target sites for autophosphorylation (Parrini et al. 2002).
Chong, C, Tan, L, Lim, L, Manser, E
Parrini, MC, Lei, M, Harrison, SC, Mayer, BJ
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