Autophosphorylation of PAK

Stable Identifier
R-HSA-2730856
Type
Reaction
Species
Homo sapiens
Compartment
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Upon dimer disassociation PAK1 autophosphorylates in both cis- and trans- manner. Serine 144 (S144) in the GTPase-binding domain and threonine 423 (T423) in the activation loop are the target sites for autophosphorylation (Parrini et al. 2002).

Literature References
PubMed ID Title Journal Year
11804587 Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

Parrini, MC, Lei, M, Mayer, BJ, Harrison, SC

Mol Cell 2002
11278486 The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

Manser, E, Lim, L, Chong, C, Tan, L

J Biol Chem 2001
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane]

Orthologous Events
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